纳米递送系统在乳腺癌治疗中的研究进展  

Research progress of nano delivery system in breast cancer treatment

作　　者：李国庆 焦萍 王瑞芳[1] 张杜娟[1] LI Guoqing;JIAO Ping;WANG Ruifang;ZHANG Dujuan(Dept.of Pharmacy,Jinan Maternity and Child Care Hospital,Jinan 250002,China)

机构地区：[1]济南市妇幼保健院药剂科,济南250002

出　　处：《中国药房》2023年第1期122-128,共7页China Pharmacy

摘　　要：乳腺癌是当下严重威胁女性健康的一种恶性肿瘤,手术治疗虽然最直接有效,但是受诸多因素限制,需辅助以其他的治疗方式。这些辅助治疗方式除常规放疗外,还有化疗、基因治疗、光疗等,但是化疗、基因治疗、光疗等使用的治疗剂往往存在水溶性、稳定性、靶向性差等缺点。随着纳米技术的出现,越来越多的学者构建并研究了治疗乳腺癌的纳米递送系统,如基于肿瘤微环境设计的响应系统、温敏响应性系统、基于肿瘤细胞膜表面特有蛋白的纳米递送系统等。笔者对此进行总结发现,这些纳米递送系统不仅提高了治疗剂的水溶性、稳定性,还能采用靶向手段等方式将其精准地递送到乳腺肿瘤部位,在提高疗效的同时降低毒副作用,可为乳腺癌的治疗药物开发和临床应用提供参考。Breast cancer is a malignant tumor that seriously threatens women’s health at present. Although surgical treatment is the most direct and effective, it is limited by many factors and needs to be assisted by other treatments. In addition to conventional radiotherapy, these adjuvant therapies also include chemotherapy, gene therapy, phototherapy and so on. However, the therapeutic agents used in these treatment methods have some limitations, such as poor water-solubility, instability and targeting. With the development of nano-technology, more and more researchers construct and study nano delivery system for breast tumor treatment, such as response system designed based on tumor microenvironment, temperature sensitive response system, nano delivery system based on specific proteins of tumor cell membrane, etc. The author summarizes the nano delivery system, and finds that these nano delivery systems can not only improve the water-solubility and stability of the therapeutic agents, but also accurately deliver them to the breast tumor site by targeted means, improve the efficacy and reduce toxic side effects, which provides new ideas for the treatment of breast cancer in the future.

关 键 词：纳米递送体系 乳腺癌 化疗 基因治疗 光疗 

分 类 号：R944[医药卫生—药剂学]