老年糖尿病患者临床检验尿白蛋白,免疫球蛋白G及β2微球蛋白临床诊断价值分析  

Clinical Diagnostic Value of Urinary Albumin, Immunoglobulin G and β2 Microglobulin in Geriatric Diabetes Mellitus

作　　者：刘红莲 陈明生[1] 林钊盛 陈莺[1] 魏慧娴 陈雯[1] 许桂珠 邓婕[1] 林志智[1] LIU Honglian;CHEN Mingsheng;LIN Zhaosheng;CHEN Ying;WEI Huixian;CHEN Wen;XU Guizhu;DENG Jie;LIN Zhizhi(Department of Hospital Infection Management,Longyan First Hospital,Affiliated Hospital of Fujian Medical University,Longyan,Fujian Province,364000 China;Department of Respiratory and Critical Care,Longyan First Hospital,Affiliated Hospital of Fujian Medical University,Longyan,Fujian Province,364000 China)

机构地区：[1]福建医科大学附属医院龙岩第一医院感染管理科,福建龙岩364000 [2]福建医科大学附属医院龙岩第一医院呼吸与危重症学科,福建龙岩364000

出　　处：《糖尿病新世界》2022年第21期1-4,共4页Diabetes New World Magazine

摘　　要：目的 分析尿白蛋白、免疫球蛋白G以及β2微球蛋白检验于老年糖尿病临床诊断中的应用价值。方法选取2020年12月—2021年12月在福建医科大学附属医院龙岩第一医院接受治疗的老年糖尿病患者180例为研究对象,作为观察组,另选取同一时段内在本院接受健康体检的180名健康体检者为对照组。比较两组尿白蛋白、免疫球蛋白G以及β2微球蛋白检验水平。同时,将观察组依据是否合并肾病分为单纯糖尿病组和糖尿病肾病组,比较两组尿白蛋白、免疫球蛋白G以及β2微球蛋白水平。结果 观察组尿白蛋白(6.19±0.82)mg/L、免疫球蛋白G(3.46±0.38)g/L以及β2微球蛋白(109.14±10.71)μg/L测定值均明显高于对照组,差异有统计学意义(t=115.317、67.557、87.171, P<0.05);单纯糖尿病组患者尿白蛋白、免疫球蛋白G以及β2微球蛋白测定值均明显低于糖尿病肾病组患者,差异有统计学意义(P<0.05)。结论 测定尿白蛋白、β2微球蛋白和免疫球蛋白,可帮助临床医务人员判断老年糖尿病患者的肾功能状态,各指标水平对病情评估而言有重要指导作用。Objective To analyze the value of urine albumin, immunoglobulin G and β2-microglobulin tests in the clinical diagnosis of geriatric diabetes mellitus.Methods 180 elderly patients with diabetes who were treated in Longyan First Hospital, Affiliated Hospital of Fujian Medical University from December 2020 to December 2021 were selected as the study subjects, as the observation group, and 180 health examinees who received physical examination in our hospital during the same period were selected as the control group. Urinary albumin, immunoglobulin G and β2microglobulin test was used to compare the levels between the two groups. At the same time, the patients in the observation group were divided into simple diabetes group and diabetes nephropathy group according to whether they had kidney disease. The urinary albumin, immunoglobulin G and β2 microglobulin level between the two groups.Results The measured values of urinary albumin was(6.19±0.82)mg/L, immunoglobulin G was(3.46±0.38)g/L and microglobulin was was(109.14±10.71)μg/L in the observation group were significantly higher than those in the control group, and the difference was statistically significant(t=115.317, 67.557, 87.171, P<0.05). The measured values of urinary albumin, immunoglobulin G and β2 microglobulin in simple diabetes group of patients were significantly lower than those in diabetes nephropathy group of patients, and the difference was statistically significant(P<0.05).Conclusion The determination of urinary albumin, β2-microglobulin and immunoglobulin can help clinical medical staff to judge the renal function status of geriatric diabetes mellitus, and each index level has an important guiding role in disease assessment.

关 键 词：老年糖尿病 尿白蛋白 Β2微球蛋白 临床诊断 免疫球蛋白G 

分 类 号：R446[医药卫生—诊断学]