2型糖尿病应用短期胰岛素强化治疗对患者血糖、血脂及胰岛功能的影响分析  

Analysis of the Effects of Applying Short-Term Insulin Intensive Therapy in Type 2 Diabetes on Patients’Blood Glucose,Blood Lipids and Islet Function

作　　者：廖志华 袁建洋 李树荣 LIAO Zhihua;YUAN Jianyang;LI Shurong(Department of Endocrinology,Shanghang County Hospital of Traditional Chinese Medicine,Longyan,Fujian Province,364200 China)

机构地区：[1]福建省龙岩市上杭县中医院内分泌科,福建龙岩364200

出　　处：《糖尿病新世界》2022年第20期73-76,共4页Diabetes New World Magazine

摘　　要：目的探究2型糖尿病应用短期胰岛素强化治疗的可行性。方法选取2019年6月—2021年6月福建省龙岩市上杭县中医院就诊的120例2型糖尿病患者为研究对象,以随机抽签法将其分为对照组与观察组,各60例。对照组患者实施口服降糖药治疗,观察组患者实施短期胰岛素治疗,对比两组患者血糖水平、血脂水平及胰岛功能。结果观察组患者糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)糖代谢水平优于对照组,差异有统计学意义(P<0.05);观察组患者三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)脂代谢水平优于对照组,差异有统计学意义(P<0.05);观察组患者FINS、HOMA-IR胰岛功能指标优于对照组,差异有统计学意义(P<0.05)。结论2型糖尿病应用短期胰岛素强化治疗,对于患者稳定血糖、血脂水平,提高胰岛功能均具有积极影响,选择优越性较高。Objective To investigate the feasibility of applying short-term insulin intensive therapy in type 2 diabetes mellitus.Methods One hundred and twenty patients with type 2 diabetes mellitus attending Shanghang County Hospital of Traditional Chinese Medicine from June 2019 to June 2021 were selected for the study.They were divided into control group and observation group by random sampling method,with 60 cases in each group.Patients in the control group were treated with oral hypoglycemic drugs,and patients in the observation group were treated with short-term insulin.The blood glucose level,lipid level and islet function of the patients in the two groups were compared.Results The glycated hemoglobin(HbA1c),fasting blood glucose(FPG)and 2 h postprandial glucose(2 hPG)glucose metabolism levels of patients in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).The lipid metabolism levels of triglyceride(TG),total cholesterol(TC),highdensity lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were better in the observation group than in the control group,and the difference was statistically significant(P<0.05).The patients in the observation group had better FINS and HOMA-IR islet function indexes than the control group,and the difference was statistically significant(P<0.05).Conclusion The application of short-term insulin intensive therapy in type 2 diabetes has a positive impact on patients’stabilization of blood glucose and lipid levels and improvement of islet function,and the superiority of selection is high.

关 键 词：2型糖尿病 胰岛素 血糖 血脂 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]