头孢克洛与头孢克肟治疗小儿急性细菌性肠炎的效果分析  

Analysis of Effect Between Cefaclor and Cefixime in Treatment of Acute Bacterial Enteritis in Children

作　　者：吴勇 林喜光 Wu Yong;Lin Xi-guang(Pediatrics Department,Hezhou People's Hospital,Hezhou 542899,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]贺州市人民医院儿科,广西贺州542899

出　　处：《中国社区医师》2022年第34期14-16,共3页Chinese Community Doctors

摘　　要：目的:分析头孢克洛与头孢克肟治疗小儿急性细菌性肠炎的临床疗效。方法:选取2018年4月-2019年9月贺州市人民医院收治的小儿急性细菌性肠炎患儿124例为研究对象,按随机数字表法分为对照组与观察组,各62例。对照组给予头孢克洛治疗,观察组给予头孢克肟治疗。比较两组治疗效果、炎性因子[C反应蛋白(CRP)、白细胞计数(WBC)]水平、临床症状改善时间、不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P <0.05);治疗后,两组患者CRP、WBC水平均降低,观察组低于对照组,差异有统计学意义(P<0.05);观察组退热时间、呕吐停止时间、大便性状复常时间、大便次数复常时间及住院时间均短于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:头孢克肟治疗小儿急性细菌性肠炎可提高临床疗效,减轻炎性反应,加快临床症状消失,缩短住院时间,且安全性高,临床效果显著。Objective: To analyze the clinical efficacy of cefaclor and cefixime in the treatment of acute bacterial enteritis inchildren. Methods: A total of 124 children with acute bacterial enteritis admitted to Hezhou People’s Hospital from April 2018 toSeptember 2019 were selected as the study subjects, and they were divided into control group and observation group by randomnumber table method, with 62 cases in each group. The control group was given cefaclor treatment, and the observation group wasgiven cefixime treatment. The treatment effect, inflammatory factors levels [C reactive protein(CRP), white blood cell count(WBC)],time to clinical symptom improvement and the incidence of adverse reactions in two groups were compared. Results: The totaleffective rate of treatment in the observation group was higher than that in the control group, and the difference was statisticallysignificant(P<0.05). After treatment, the levels of CRP and WBC in two groups were reduced, and the observation group was lowerthan the control group, and the difference was statistically significant(P<0.05). The time of fever clearance, vomiting cessation,restoring to normal stool trait, restoring to normal bowel movement frequency and the length of hospital stay in the observation groupwere shorter than those in the control group, and the difference was statistically significant(P<0.05). There was no statisticallysignificant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Cefixime in the treatmentof pediatric acute bacterial enteritis can improve clinical efficacy, alleviate inflammatory reaction, accelerate the disappearance ofclinical symptoms, shorten the length of hospital stay, and have high safety and significant clinical effect.

关 键 词：小儿急性细菌性肠炎 头孢克肟 头孢克洛 炎性因子 

分 类 号：R725.7[医药卫生—儿科]