Limited cross-variant neutralization after primary Omicron infection:consideration for a variant-containing booster  

作　　者：Harold Marcotte Lennart Hammarstrom Qiang Pan-Hammarstrom 

机构地区：[1]Department of Biosciences and Nutrition,Karolinska Institutet,14157 Huddinge,Sweden

出　　处：《Signal Transduction and Targeted Therapy》2022年第9期3174-3176,共3页信号转导与靶向治疗（英文）

基　　金：H.M,L.H,and Q.P.H.are supported by the European Union's Horizon 2020 research and innovation program under grant agreement No 101003650(ATAC);the Swedish Research Council,and the Knut and Alice Wallenberg Foundation(KAW).

摘　　要：In a recent study published in Nature,Suryawanshi et al.showed that primary Omicron infection only elicits a mild humoral immune response and limited cross-variant neutralization in non-vaccinated individuals.1On the other hand,vaccinated individuals developed high neutralizing antibody titers against all variants of concern(VOCs)following breakthrough Omicron infections.Hence,Omicron infection can enhance existing immunity induced by vaccination but may not prevent reinfection by other VOCs in non-vaccinated individuals.

关 键 词：BREAKTHROUGH immunity OMI 

分 类 号：R373[医药卫生—病原生物学]