迈之灵片联合体外冲击波碎石术治疗输尿管上段结石的临床疗效  

Clinical Efficacy of Aescin Tablet Combined with Extracorporeal Shock Wave Lithotripsy in the Treatment of Upper Ureteral Calculus

作　　者：张恩溥 刘南新 苏冠宇 王舟怡 李国 黄桂晓[1] ZHANG En-Pu;LIU Nan-Xin;SU Guan-Yu;WANG Zhou-Yi;LI Guo;HUANG Gui-Xiao(Urology Surgery of Luohu District People's Hospital,Shenzhen 51800l,China)

机构地区：[1]深圳市罗湖区人民医院泌尿外科,广东深圳518001

出　　处：《中国药物经济学》2022年第10期65-68,72,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨迈之灵片联合坦索罗辛胶囊对单侧输尿管上段结石在体外冲击波碎石术(ESWL)后的辅助排石作用。方法选取2018年12月至2020年12月于深圳市罗湖区人民医院住院治疗的100例单侧输尿管上段结石患者作为研究对象,随机分为4组:迈之灵片联合坦索罗辛胶囊组(A组)、迈之灵片组(B组)、坦索罗辛胶囊组(C组)及对照组(D组)。4组患者在行ESWL后均给予间苯三酚及中药排石制剂等综合排石治疗,对照组患者不给予迈之灵片及坦索罗辛胶囊。比较4组患者结石排出率、排出时间、结石成分、肾绞痛发作及使用药物镇痛情况、肾绞痛发作时疼痛评分,同时记录患者用药后不良反应发生情况。结果4组患者1周输尿管结石排出率比较发现A组结石排出率最高,D组则最低;2周及3周输尿管结石排出率比较差异无统计学意义(P>0.05);A组结石排出时间短于其他组(P<0.05),B组结石排出时间短于C组和D组(P<0.05);4组患者肾绞痛发作时疼痛评分比较差异有统计学意义(P<0.05)。所有服用迈之灵片的患者均未出现明显胃肠不适症状。结论迈之灵片联合坦索罗辛胶囊可明显缩短ESWL后单侧输尿管上段结石排出时间并显著减轻排石引起的肾绞痛,且不良反应少,耐受性良好。Objective To explore the effect of Aescin tablet combined with tamsulosin capsule on assisting stone removal of unilateral upper ureteral calculi after extracorporeal shock wave lithotripsy(ESWL).Methods 100 patients with unilateral upper ureteral calculi hospitalized in Shenzhen Luohu District People’s Hospital from December 2018 to December 2020 were selected as the study subjects,and randomly divided into 4 groups:Aescin Tablet combined with tamsulosin capsule group(Group A),Aescin Tablet group(Group B),tamsulosin capsule group(Group C)and control group(Group D).After ESWL,the patients in the four groups were treated with phloroglucinol and traditional Chinese medicine lithotripsy preparation,while the patients in the control group were not given Maizhiling tablets and tamsulosin capsules.The stone excretion rate,excretion time,stone composition,renal colic attack and drug analgesia,and pain score during renal colic attack were compared among the four groups,and the adverse reactions after medication were recorded.Results One week ureteral stone excretion rate in group A was the highest,while that in group D was the lowest;There was no significant difference in the rate of ureteral stone excretion between 2 weeks and 3 weeks(P>0.05);The stone excretion time of group A was shorter than that of other groups(P<0.05),while that of group B was shorter than that of group C and group D(P<0.05);The pain scores of renal colic attack in the four groups were statistically significant(P<0.05).All patients taking Maizhiling tablets did not show obvious gastrointestinal discomfort.Conclusion Aescin tablet combined with tamsulosin capsule can significantly shorten the time of stone excretion in the upper part of unilateral ureter after ESWL and significantly reduce renal colic caused by stone expulsion,with few adverse reactions and good tolerance.

关 键 词：迈之灵片 输尿管上段结石 体外冲击波碎石术 坦索罗辛胶囊 

分 类 号：R693[医药卫生—泌尿科学] R982[医药卫生—外科学]