注射用阿莫西林钠克拉维酸钾与0.9%氯化钠注射液配伍的稳定性  

The Stability of Amoxicillin Sodium and Clavulanate Potassium Dissolved in Normal Saline

作　　者：魏永涛 张红梅 王桂英 崔玉玲 WEI Yong-Tao;ZHANG Hong-Mei;WANG Gui-Ying;CUI Yu-Ling(Jinan Food and Drug Inspection Center,Jinan 250014,China)

机构地区：[1]济南市食品药品检验检测中心,济南250014

出　　处：《中国药物经济学》2022年第10期119-122,126,共5页China Journal of Pharmaceutical Economics

摘　　要：目的考察注射用阿莫西林钠克拉维酸钾与0.9%氯化钠注射液配伍后的稳定性,为临床用药提供参考。方法用高效液相色谱法测定不同企业产品用0.9%氯化钠注射液溶解后,阿莫西林钠克拉维酸钾在不同时段的含量变化情况。结果不同企业的产品配液后的变化无明显差异。初始加入0.9%氯化钠注射液10 ml或20 ml,放置10 min,阿莫西林钠含量下降约10%、克拉维酸钾含量下降约15%。结论注射用阿莫西林钠克拉维酸钾稳定性不佳,放置时间越长,溶液浓度越高,稳定性越差,用0.9%氯化钠注射液溶解后,应立即稀释至规定用量。Objective To study the stability of amoxicillin sodium and clavulanate potassium for injection in normal saline so as to offer a scientific basis for the clinical use of the products.Methods By HPLC,assay the solutions of amoxicillin sodium and clavulanate potassium dissolved in NS from several plants,and then survey the divergence between different durations.Results There is no significant difference in the contents of the kinds of products.When 10 ml or 20 ml NS was added and placed for 10min,the content of amoxicillin sodium decreased by 10%approximately,and the content of clavulanate potassium decreased by 15%approximately.Conclusion The solution of amoxicillin sodium and clavulanate potassium in NS has poor stability,especially when in a high concentration,and/or placed for a long time.It should be prepared promptly before clinical use,and dissolved in specified volume.

关 键 词：注射用阿莫西林钠克拉维酸钾 0.9%氯化钠注射液 含量测定 配伍稳定性 

分 类 号：R978.1[医药卫生—药品]