盐酸氨酮戊酸联合聚甲酚磺醛治疗女性尖锐湿疣的临床研究  

Clinical study on aminolevulinic acid hydrochloride combined with Policresulen Suppositories in treatment of condyloma acuminatum in women

作　　者：翟伟[1] 翟翊然[1] 王瑾 闪海霞[3] ZHAI Wei;ZHAI Yi-ran;WANG Jin;SHAN Hai-xia(Department of Dermatology,Nanyang Central Hospital,Nanyang 473000,China;Sheqi County People’s Hospital,Nanyang 473300,China;Department of Infectious Disease,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院皮肤科,河南南阳473000 [2]社旗县人民医院,河南南阳473300 [3]南阳市中心医院感染科,河南南阳473000

出　　处：《现代药物与临床》2022年第11期2598-2602,共5页Drugs & Clinic

基　　金：河南省医学科技攻关计划普项目(LHGJ20200905)。

摘　　要：目的探讨盐酸氨酮戊酸联合聚甲酚磺醛治疗尖锐湿疣的临床疗效。方法选择2021年4月—2022年4月在南阳市中心医院治疗的98例尖锐湿疣女性患者,根据用药的差别分为对照组和治疗组,每组各49例。对照组给予聚甲酚磺醛栓,置入阴道内,1枚/次,隔日1次。在此基础上,治疗组给予盐酸氨酮戊酸外用散,配成20%的溶液,每隔30分钟敷用1次,持续敷药3h,用氦氖激光照射,每周1次。两组连续治疗4周。观察两组患者临床疗效,比较治疗前后两组患者临床症状改善时间,CECA10评分、GSES评分、FS-36评分和NRS评分,血清可溶性白细胞介素-2受体(s IL-2R)、γ干扰素(IFN-γ)、白细胞介素-18(IL-18)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-23(IL-23)和低氧诱导因子-1α(HIF-1α)水平。结果治疗后,治疗组总有效率为97.96%,显著高于对照组(83.67%,P<0.05)。治疗后,疣状物消失、外阴瘙痒、外阴疼痛、恶臭味等症状消失时间均早于对照组(P<0.05)。治疗后,两组CECA10评分、GSES评分、FS-36评分均明显升高,而NRS评分明显下降(P<0.05),并且治疗组评分明显好于对照组(P<0.05)。治疗后,两组患者血清sIL-2R、IL-18、GM-CSF、HIF-1α水平明显降低,而IIFN-γ和IL-23水平明显升高(P<0.05),且治疗组细胞因子水平明显好于对照组(P<0.05)。结论盐酸氨酮戊酸联合聚甲酚磺醛治疗尖锐湿疣可有效改善患者症状,降低炎症反应,提高性生活质量及自我效能水平。Objective To explore the clinical efficacy of aminolevulinic acid hydrochloride combined with Policresulen Suppositories in treatment of condyloma acuminatum. Methods Female patients(98 cases) with condyloma acuminatum in Nanyang Central Hospital from April 2021 to April 2022 were divided into control and treatment group based on different treatments, and each group had 49 cases. Patients in the control group were administered with Policresulen Suppositories, 1 suppository at a time in the vagina,once every other day. Patients in the treatment group were administered with Aminolevulinic Acid Hydrochloride Topical Powder on the basis of the control group, prepared 20% solution, applied every 30 min for 3 h, irradiated by He-Ne laser, once weekly. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluation was evaluated, the improvement time of symptom, the scores of CECA10, GSES, FS-36 and NRS, the levels of cytokine sIL-2R, IL-18, GM-CSF, HIF-1α, IIFN-γ, and IL-23 in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 97.96%,significantly higher than that of the control group(83.67%, P < 0.05). After treatment, the disappearance time of warts, vulvar pruritus,vulvar pain, odor and other symptoms were earlier than those of the control group(P < 0.05). After treatment, the CECA10 score,GSES score, and FS-36 score in two groups were significantly increased, while the NRS score were significantly decreased(P < 0.05),and these scores in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the serum levels of sIL-2R, IL-18, GM-CSF and HIF-1α in two groups were significantly decreased, while the levels of IIFN-γ and IL-23 were significantly increased(P < 0.05), and the cytokine level in the treatment group was significantly better than that in the control group(P < 0.05). Conclusion Aminolevulinic acid hydrochloride combined with Policresulen Suppositories i

关 键 词：盐酸氨酮戊酸外用散 聚甲酚磺醛栓 尖锐湿疣 可溶性白细胞介素-2受体 粒细胞-巨噬细胞集落刺激因子 低氧诱导因子-1Α 

分 类 号：R984[医药卫生—药品]