补肾固齿丸联合聚维酮碘治疗慢性牙周炎的临床研究  

Clinical study on Bushen Guchi Pills combined with povidone-iodine in treatment of chronic periodontitis

作　　者：何淼 邬礼政 陈思果 朱志颖 HE Miao;WU Li-zheng;CHEN Si-guo;ZHU Zhi-ying(Department of Stomatology,Characteristic Medical Center of the Chinese People’s Armed Police Force,Tianjin 300100,China)

机构地区：[1]中国人民武装警察部队特色医学中心口腔科,天津300100

出　　处：《现代药物与临床》2022年第11期2612-2615,共4页Drugs & Clinic

基　　金：天津市科技计划项目(17JCTPJC0465)。

摘　　要：目的 探讨补肾固齿丸联合聚维酮碘治疗慢性牙周炎的临床疗效。方法 2019年10月—2021年10月在中国人民武装警察部队特色医学中心诊治的106例患者,随机分对照组和治疗组,每组各53例。对照组患者含漱聚维酮碘含漱液,10 mL/次,含漱10 s后弃去,4次/d。在对照组的基础上,治疗组口服补肾固齿丸,4 g/次,2次/d。两组用药14 d。观察两组患者临床疗效,比较治疗前后两组患者症状好转时间,牙周菌斑指数评分(PLI)、出血指数评分(BI)、牙龈指数评分(GI)评分,血清因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平。结果 治疗后,治疗组的临床有效率(98.11%)明显高于对照组(81.13%,P<0.05)。治疗后,治疗组患者牙龈水肿、牙齿松动、咀嚼疼痛、口腔异味等症状好转时间均早于对照组(P<0.05)。治疗后,两组患者牙周PLI、BI、GI评分明显降低(P<0.05),且治疗后治疗组评分明显均低于对照组(P<0.05)。治疗后,两组血清因子IL-6、IL-1β、TNF-α、CRP水平均明显下降(P<0.05),且治疗组水平均低于对照组(P<0.05)。结论 补肾固齿丸联合聚维酮碘治疗慢性牙周炎,可有效改善患者症状及牙周状态,并能促进机体炎症反应降低,且安全有效。Objective To explore the clinical study of Bushen Guchi Pills combined with povidone-iodine in treatment of chronic periodontitis. Methods Patients(106 cases) with chronic periodontitis in Characteristic Medical Center of the Chinese People’s Armed Police Force from October 2019 to October 2021 were randomly divided into control and treatment group, and each group had 53 cases.Patients in the control group gargled with Povidone-iodine Gargle and Mouthwash, 10 mL/time for 10 second, four times daily. Patients in the treatment group were po administered with Bushen Guzhi Pills on the basis of the control group, 4 g/time, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical evaluation was evaluated, the improvement time of symptom,periodontal PLI, BI and GI score, serum factors IL-6, IL-1β, TNF-α and CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical therapeutic efficiency of the treatment group(98.11%) was significantly higher than that of the control group(81.13%, P < 0.05). After treatment, the improvement time of gingival edema, loose teeth, masticatory pain and bad breath in the treatment group was earlier than that in the control group(P < 0.05). After treatment, the periodontal PLI, BI and GI scores in two groups were significantly decreased(P < 0.05), and the scores of the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the serum levels of IL-6, IL-1β, TNF-α and CRP in two groups were significantly decreased(P < 0.05), and the levels in the treatment group were lower than those in the control group(P < 0.05). Conclusion The combination of povidone iodine and Bushen Guye Pills can effectively improve the symptoms and periodontal state of the patients,promote the reduction of inflammatory reaction, and which is safe and effective.

关 键 词：补肾固齿丸 聚维酮碘含漱液 慢性牙周炎 菌斑指数评分 出血指数评分 牙龈指数评分 肿瘤坏死因子-α 

分 类 号：R988.2[医药卫生—药品]