儿童铝负荷状况及铝神经毒作用机制的研究进展  

Research progress on aluminum load in children and the mechanism of aluminum neurotoxicity

作　　者：裴静 张立丰 PEI Jing;ZHANG Lifeng(Department of Maternal,Child and Adolescent Health,School of Public Health,Shenyang Medical College,Shenyang 110034,China)

机构地区：[1]沈阳医学院公共卫生学院儿少卫生与妇幼保健学教研室,辽宁110034

出　　处：《中国学校卫生》2022年第11期1755-1760,共6页Chinese Journal of School Health

基　　金：国家自然科学基金面上项目(81673226);辽宁省科技厅科学技术研究项目(201601226);辽宁省教育厅科学技术研究面上项目(LJKZ1146)。

摘　　要：铝是一种慢性蓄积性环境神经毒物。随着人体铝接触途径的多样化和不可避免性,其铝负荷水平呈上升趋势,长期铝负荷导致的神经生物毒性受到广泛关注。对于生长发育迅速的儿童来说,铝摄入量、铝吸收率以及体内铝负荷水平往往高于普通成人。长期持续低剂量铝负荷可能给儿童神经发育功能造成各种慢性亚临床损害及远期不可逆危害。鉴于以上背景,本文主要从儿童铝负荷状况、铝负荷对其神经发育功能的影响及神经发育功能受损相关机制的研究进展等方面进行阐述,为预防或治疗儿童铝负荷引起的健康问题提供理论依据,同时为儿童预防保健工作提供发展思路。Aluminum is a chronic and cumulative environmental neurotoxin. Human exposure to aluminum is inevitable and impossible to quantify. The level of aluminum load is on the rise, the neurobiological toxicity of which is a cause for great concern. Aluminum intake, absorption, and load levels in the body are often higher in children in stages of rapid growth and development than in ordinary adults. Long-term low-dose aluminum load levels may cause a variety of chronic subclinical damage and long-term irreversible damage to the neurodevelopmental function of children. Therefore, this review primarily elucidates the status of aluminum load in children and its effect on neurodevelopmental functioning. Furthermore, we examine research progress on the related mechanism of impaired neurodevelopmental functioning so as to provide a theoretical basis for the treatment and prevention of health problems caused by aluminum load in children and outline proposals for healthcare in this area.

关 键 词：铝 全身负荷 中毒 儿童 

分 类 号：R446[医药卫生—诊断学] R179[医药卫生—临床医学]