清肝降压胶囊联合卡维地洛片治疗肝经郁热型高血压合并慢性心率增快疗效观察  

Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome

作　　者：石洁[1] 商秀洋[1] 王丽昀[2] SHI Jie;SHANG Xiu-yang;WANG Li-yun(Cardiovascular Department,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Preventive Health Care Section,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院心血管科,北京100053 [2]中国中医科学院广安门医院预防保健科,北京100053

出　　处：《北京中医药》2022年第10期1115-1118,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医临床基地业务建设第二批科研专项(JDZX2015142)。

摘　　要：目的观察清肝降压胶囊联合卡维地洛片治疗肝经郁热型高血压合并慢性心率增快患者的疗效及安全性。方法选择2018年10月―2020年7月于中国中医科学院广安门医院心血管科门诊就诊的静息心率>80次/min、肝经郁热型1、2级高血压患者122例,按照随机数字表法分为单药组和联合组。单药组予卡维地洛10 mg/次,2次/d;联合组在此基础上予清肝降压胶囊1.5 g/次,3次/d。2周后血压不达标的患者卡维地洛加量为20 mg/次,2次/d,疗程为4周。对比2组治疗前后血压、心率、中医证候评分及疗效、安全性。结果治疗2、4周2组SBP、DBP、静息心率均较治疗前降低(P<0.05);治疗4周联合组SBP低于单药组(P<0.05)。治疗4周后,联合组血压达标率高于单药组(P<0.05);2组心率达标率、卡维地洛加量患者比例比较,差异均无统计学意义(P>0.05)。治疗后2组中医证候积分均较治疗前降低(P<0.05),且联合组中医证候积分低于单药组(P<0.05)。联合组总有效率高于单药组(P<0.05),2组治疗后均未出现不良反应。结论清肝降压胶囊联合卡维地洛可以提高合并慢性心率增快的肝经郁热型1、2级高血压患者的血压达标率,且改善患者的临床症状,疗效优于单纯卡维地洛治疗。Objective To explore the clinical effect and safety of Qinggan Jiangya Capsules combined with Carvedilol Tablets for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome.Methods 122 patients with grade1 and 2 hypertension with resting heart rate>80 beats/min of stagnated heat of liver meridian syndrome admitted to the Cardiovascular Department,Guang’anmen Hospital,China Academy of Chinese Medical Sciences from October 2018 to July 2020 were selected and randomly divided into single-drug group and combined-therapy group according to the random number table method.Single-drug group was prescribed Carvedilol 10mg Bid and combined-therapy group was prescribed Carvedilol 10 mg Bid and Qinggan Jiangya Capsules 0.9 g three times a day.Those whose blood pressure didn’t reach target control were prescribed Carvedilol 20 mg Bid after two weeks and the whole course was four weeks.The blood pressure,heart rate,TCM syndrome score,curative effect and safety were compared between the two groups before and after treatment.Results After two and four weeks,not only SBP and DBP,but also rest heart rate in two groups were decreased significantly(P<0.05).After 4 weeks of treatment,SBP in the combined group was lower than that in the single drug group(P<0.05),the blood pressure compliance rate of combined group was higher than that of single drug group(P<0.05).There was no significant difference between the two groups in heart rate compliance rate and the ratio of Carvedilol to 20 mg twice a day(P>0.05).TCM syndrome scores of both groups were significantly decreased after treatment(P<0.05).The TCM syndrome scores of combined-therapy group patients were significantly lower than those of single-drug group patients(P<0.05).The total effective rate of TCM syndrome in combined-therapy group was significantly higher than that in singledrug group and the difference was of statistical significant(P<0.05).There were no adverse reactions in both groups after treatment.Conclusion Qinggan Jiangy

关 键 词：高血压 慢性心率增快 清肝降压胶囊 卡维地洛 肝经郁热证 

分 类 号：R544.1[医药卫生—心血管疾病] R541.7[医药卫生—内科学]