含甘青青兰藏药方剂的配伍规律及临床用药研究  

Study on the Prescription and Medication Rule of Prescription Contain Tibetan Herbal Medicine Ganqingqinglan(Dracocephalum Tanguticum)Based on Data Mining

作　　者：安拉太 张思德 秀老 郭肖 嘎务 李啟恩 Anlatai;ZHANG Side;Xiulao;GUO Xiao;Gawu;LI Qien(Tibetan Medical College/Tibetan Medicine Research Center,Qinghai University,Xi'ning Qinghai 810016,China;Qinghai Provincial Corps Hospital of the Armed Police Force,Xi'ning Qinghai 810000,China;Department of Tibetan Medicine,Tibetan Traditional Medical University of Tibet,Lhasa Tibet 850000,China)

机构地区：[1]青海大学藏医学院/藏医药研究中心,青海西宁810016 [2]武警青海省总队医院,青海西宁810000 [3]西藏藏医药大学藏药系,西藏拉萨850000

出　　处：《中医药导报》2022年第12期148-152,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：青海省自然基金面上项目(2019-ZJ-907);国家中医药领军人才支持计划“青年岐黄学者”支持项目。

摘　　要：目的:研究甘青青兰在藏医临床中的用药规律及含该药材方剂的配伍规律,为临床合理用药及新处方的发现提供参考依据。方法:通过检索《藏药方剂大全》等藏医药文献搜集含甘青青兰的藏药方剂,运用Microsoft Excel 2019对含甘青青兰的方剂进行数据整理,并运用SPSS Modeler 18.0对数据库的药物进行频数统计和关联规则(Apriori)分析,利用Gephi 0.9.2作相关网络展示图。结果:共收集到含甘青青兰的方剂126首,涉及主治疾病125种,包含常用藏药材307味。同甘青青兰配伍用药频数最高的药物分别为诃子、红花和蒂达。甘青青兰多与清血、消热、解毒类药物配伍使用。含甘青青兰方剂的剂型以散剂最多,主要治疗木布病。关联规则分析发现频数、置信度、支持度均高的二项关联药物组合为甘青青兰-诃子、甘青青兰-红花和甘青青兰-蒂达;三项关联药物组合为甘青青兰-红花-诃子。含甘青青兰藏药方剂治疗木布病、中毒症和肝热症时多与清血热、解毒和安抚“隆”类药物搭配使用,且根据个体差异和时间等因素,需要对方剂进行加减组方,以提高临床治疗效果,反映出独特的藏医用药思路。结论:甘青青兰在藏医临床中常与红花、蒂达、渣驯等搭配使用,主要用于清热解毒和保肝镇痛,且在治疗木布病、肝热病和中毒症等不同疾病时具有明显的配伍和剂型选择差异,这一差异在藏医临床用药和新药开发时有必要关注和重视。Objective:To study the medication rule of Ganqingqinglan(Dracocephalum Tanguticum)in Tibetan medicine and the compatibility rules of prescriptions containing this medicinal material,so as to provide reference for clinical rational drug use and discovery of new prescriptions.Methods:The Tibetan medicine prescriptions containing Ganqingqinglan(Dracocephalum Tanguticum)were collected from Tibetan medical literatures such as A Complete Collection Of Tibetan Medicine Prescriptions.Microsoft Excel 2019 was used to sort out the data of the prescriptions containing Ganqingqinglan(Dracocephalum Tanguticum),and SPSS Modeler 18.0 was used to conduct frequency statistics and association rule analysis on the drugs in the database,using Gephi 0.9.2 for the relevant network display map.Results:A total of 126 prescriptions containing Ganqingqinglan(Dracocephalum Tanguticum)were collected,including 307 commonly used Tibetan medicinal materials,which were used to treat 125 major diseases.The most frequently used drugs in combination with Ganqingqinglan(Dracocephalum Tanguticum)were Hezi(myrobalan),Honghua(safflower)and Dida(chirata).Ganqingqinglan(Dracocephalum Tanguticum)is used in combination with blood-clearing,antipyretic and detoxifying drugs.The dosage form of Ganqingqinglan(Dracocephalum Tanguticum)prescription is mostly powder,which mainly treats Mubu disease(木布病).Association rule analysis found that the two associated drug combinations with high frequency,confidence drug combinations were Ganqingqinglan(Dracocephalum Tanguticum)-Honghua(Safflower)-Hezi(myrobalan).Tibetan medicine prescriptions containing Ganqingqinglan(Dracocephalum Tanguticum)are often used in combination with medicines to clear blood heat,detoxify and soothe Long in the treatment of Mubu disease,poisoning and liver fever.According to factors such as individual differences and time,it is necessary to add or subtract medicines to the prescription to improve the clinical treatment effect.This phenomenon reflects the unique thinking of Tibetan medicin

关 键 词：藏药 甘青青兰 用药规律 配伍规律 

分 类 号：R291.408[医药卫生—民族医学]