利多卡因静脉输注对腹腔镜胆囊切除术后疼痛及应激、炎性反应的影响  

Effect of Intravenous Infusion of Lidocaine on Pain,Stress and Inflammatory Response after Laparoscopic Cholecystectomy

作　　者：顾兵[1] 倪绍端 GU Bing;NI Shaoduan(Department of Anesthesiology,Siyang County Hospital of Traditional Chinese Medicine,Suqian,Jiangsu Province,223700 China)

机构地区：[1]泗阳县中医院麻醉科,江苏宿迁223700

出　　处：《系统医学》2022年第19期75-78,共4页Systems Medicine

摘　　要：目的探讨在腹腔镜胆囊切除术中静脉输注利多卡因对疼痛及应激、炎性反应的影响。方法选取2019年12月—2021年6月在泗阳县中医院接受治疗的82例腹腔镜胆囊切除术患者作为研究对象。根据随机数表法将患者分为治疗组42例与对照组40例,对照组采用常规全麻用药,治疗组在对照组的基础上联用利多卡因。对两组患者的视觉模拟评分(VAS)、血浆皮质醇(Cor)、白细胞介素(IL)-4的变化水平及术后不良反应发生情况进行比较。结果治疗组术后VAS评分较对照组明显更低,差异有统计学意义(P<0.05)。治疗组术后12 h血浆Cor、IL-4浓度与术前比较,差异无统计学意义(P>0.05);对照组术后12 h血浆Cor、IL-4浓度较术前明显升高,且高于治疗组,差异有统计学意义(P<0.05)。治疗组患者不良反应发生率(7.14%)显著低于对照组(25.00%),差异有统计学意义(χ^(2)=4.897,P<0.05)。结论在腹腔镜胆囊切除术中静脉输注利多卡因有利于降低术后疼痛感、减轻应激反应和炎症反应。Objective To investigate the effect of intravenous infusion of lidocaine on pain,stress and inflammatory response in laparoscopic cholecystectomy.Methods A total of 82 patients with laparoscopic cholecystectomy treated in Siyang Hospital of Traditional Chinese Medicine from December 2019 to June 2021 were selected as the research objects.According to the random number table method,the patients were divided into the treatment group(42 cases)and the control group(40 cases).The control group received conventional general anesthesia,and the treatment group received lidocaine on the basis of the control group.The visual analogue scale(VAS),plasma cortisol(Cor)and interleukin-4(IL-4)levels and the incidence of postoperative adverse reactions were compared between the two groups.Results The VAS score of the treatment group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the concentration of plasma Cor and IL-4 in the treatment group 12 after operation compared with that before operation(P>0.05);compared with that before operation,the concentration of plasma Cor and IL-4 in the control group increased significantly 12 hours after operation,and higher than that in the treatment group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group(7.14%)was significantly lower than that in the control group(25.00%),and the difference was statistically significant(χ^(2)=4.897,P<0.05).Conclusion Intravenous infusion of lidocaine during laparoscopic cholecystectomy can reduce postoperative pain,stress reaction and inflammatory reaction.

关 键 词：利多卡因 腹腔镜胆囊切除 术后疼痛 应激反应 炎性反应 

分 类 号：R614[医药卫生—麻醉学]