结直肠癌影像基因组学的研究进展  

Research progress of colorectal cancer radiogenomics

作　　者：贾露露 崔雅琼 黄刚[2] JIA Lulu;CUI Yaqiong;HUANG Gang(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Radiology,Gansu Provincial People's Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院放射科,兰州730000

出　　处：《磁共振成像》2022年第12期159-162,共4页Chinese Journal of Magnetic Resonance Imaging

摘　　要：结直肠癌(colorectal cancer,CRC)是目前我国发病率及死亡率最高的恶性肿瘤之一。基因分型对CRC患者的个性化治疗和预后分析有重要的指导意义。影像基因组学通过提取及分析大量的图像特征,建立肿瘤基因型和影像学表型之间的联系,可以在术前无创地预测肿瘤相关的基因型。目前,越来越多的研究致力于分析图像特征与CRC基因型的相关性,为CRC基因型的诊断和预测提供了更精准的信息。本综述将对基于CRC的影像基因组学的临床应用、发展前景以及目前在工作中展现出来的缺陷进行总结,以便于临床工作者更好地了解CRC的影像基因组学,并将其更广泛地应用于临床工作中,为临床诊疗工作提供新的诊疗方法和思路。Colorectal cancer(CRC)is one of the malignant tumors with the highest morbidity and mortality in China.Genotyping has important guiding significance for personalized treatment and prognostic analysis of CRC patients.By extracting and analyzing a large number of image features and establishing the link between tumor genotype and imaging phenotype,radiomics can non-invasively predict tumor-related genotypes before surgery.At present,more and more research is devoted to analyzing the correlation between image characteristics and CRC genotypes,which provides more accurate information for the diagnosis and prediction of CRC genotypes.This review will summarize the clinical application,development prospects and current shortcomings of CRC radiogenomics,in order to facilitate clinicians to better understand CRC radiogenomics and apply it more widely in clinical work,and provide new diagnosis and treatment methods and ideas for clinical diagnosis and treatment.

关 键 词：结直肠癌 影像组学 影像基因组学 分子分型 鼠类肉瘤病毒癌基因 微卫星不稳定性 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.3[医药卫生—诊断学]