Improving in vivo Uranyl Removal Efficacy of a Nano-Metal Organic Framework by Interior Functionalization with 3-Hydroxy-2-pyridinone  

作　　者：Mengping Chen Lang Lang Lei Chen Xiaomei Wang Cen Shi Qiwen Sun Yigong Xu Juan Diwu Shuao Wang 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou,Jiangsu,215123 China

出　　处：《Chinese Journal of Chemistry》2022年第17期2054-2060,共7页中国化学（英文版）

基　　金：supported bygrants fromthe National Natural Science Foundation of China(Nos.21976127,21790370,22106116,U2167222);the Natural Science Foundation of Jiangsu Province(Nos.BK20190044,BK20210736);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the China Postdoctoral Science Foundation(No.2020M681716);the Undergraduate Training Program for Innovation and Entrepreneurship of Soochow University(No.202010285055Z).

摘　　要：The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites,which eventually leads to the internal uranium exposure of people,causing consequential injuries of renal failure,osteosarcoma,etc.The development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear industry.Metal organic frameworks(MOFs)already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling,uranium extraction from seawater,as well as environmental decontamination.Herein,a chromium-based nano-metal organic framework(nano-MOF)functionalized interiorly with 3,2-HOPO ligands,MIL-101-HOPO,is rationally synthesized.In vitro adsorption experiments show that MIL-101-HOPO exhibits high adsorption selectivity and fast adsorption kinetics for uranyl.The results of in vivo uranyl decorporation assays reveal that MIL-101-HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs,and is more effective than the clinically used ZnNa_(3)-DTPA.All those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents.

关 键 词：Metal-organic frameworks URANIUM 3 2-HOPO Adsorption SEQUESTRATION 

分 类 号：O62[理学—有机化学]