Design, Synthesis and Application of Multifunctional Chiral Aminophosphine Catalyst for Asymmetric Intermolecular Cross Rauhut-Currier Reaction  

作　　者：Wu-Wei Dong Kui Tian Xiu-Qin Dong Chun-Jiang Wang 

机构地区：[1]Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei,430072 China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,230021 China [3]Suzhou Institute of Wuhan University,Suzhou,Jiangsu,215123 China

出　　处：《Chinese Journal of Chemistry》2022年第17期2061-2066,共6页中国化学（英文版）

基　　金：support from the National Natural Science Foundation of China(Grant Nos.22071186,22071187);the Natural Science Foundation of Hubei Province(Grant Nos.2020CFA036,2021CFA069);the Natural Science Foundation of Jiangsu Province(Grant No.BK20190213);the Fundamental Research Funds for the Central Universities(Grant No.2042022kf1180).

摘　　要：A series of structurally novel multifunctional chiral aminophosphine catalysts were developed through a concise synthetic strategy from easily available starting materials.The highly enantioselective intermolecular cross Rauhut-Currier reactions of vinyl ketones with 3-acyl acrylates and 2-ene-1,4-diones catalyzed by(S,S)-5a were well realized,generating a wide range of the structurally important chiral multicarbonyl products in good to excellent yields with high stereocontrol(up to 97%yield,99%ee).In addition,a series of 31P NMR experiments were carried out to further investigate the catalytic process.

关 键 词：Asymmetric catalysis Chiral aminophosphine Intermolecular cross Rauhut-Currier reaction Chiral multicarbonyl molecules Enantioselectivity 

分 类 号：O62[理学—有机化学]