Three-Dimensional sp^(2) Carbon-Linked Covalent Organic Frameworks as a Drug Carrier Combined with Fluorescence Imaging  

作　　者：Li Liao Zerong Zhang Xinyu Guan Hui Li Yaozu Liu Minghao Zhang Bin Tang Valentin Valtchev Yushan Yan Shilun Qiu Xiangdong Yao Qianrong Fang 

机构地区：[1]State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,Jilin University,Changchun,Jilin,130012 China [2]Deakin University,Institute for Frontier Materials,Geelong,Victoria,3216 Australia [3]Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,189 Songling Road,Laoshan District,Qingdao,Shandong,266101 China [4]Normandie Univ,ENSICAEN,UNICAEN,CNRS,Laboratoire Catalyse et Spectrochimie,6 Marechal Juin,14050 Caen,France [5]Department of Chemical and Biomolecular Engineering,Center for Catalytic Science and Technology,University of Delaware,Newark,DE,19716 USA

出　　处：《Chinese Journal of Chemistry》2022年第17期2081-2088,共8页中国化学（英文版）

基　　金：supported bythe National Natural Science Foundation of China(Nos.22025504,21621001,21390394,and 22105082);"111"project(Nos.BP0719036 and B17020);China Postdoctoral Science Foundation(Nos.22020TQ0118 and 2020M681034);the program for JLU Science and Technology Innovative Research Team.V.V.,S.Q.and Q.F.acknowledge funding from the French-Sino International Laboratory(LIA)"Zeolites"。

摘　　要：Three-dimensional(3D)covalent organic frameworks(COFs)are crystalline porous polymers with potential in numerous high-tech applications,but the linkages involved in their synthesis are still rather limited.Herein,we report novel 3D sp^(2) carbon-linked COFs fabricated by the formation reaction of C=C bonds and their application in fluorescence imaging.These new COFs,namely JUC-580 and JUC-581,show high stability and excellent light-emitting properties in solid state and dispersed in various solvents.Furthermore,we investigate the potential application of JUC-581 as a drug carrier combined with fluorescence imaging.These results indicate that 3D sp^(2) carbon-linked COFs are not only potential drug-loaded and sustained release materials but also promising cell fluorescent stains.This study thus expands the structural categories of 3D COFs based on different linkages,and promotes their prospective applications for biomedicine and fluorescent materials.

关 键 词：Covalent organic frameworks Crystalline porous materials Microporous materials Fluorescence imaging Drug delivery 

分 类 号：O62[理学—有机化学]