产气荚膜梭菌毒素研究进展  

Progress in research of Clostridium perfringens toxin

作　　者：郑浩然 白璐璐 王媛媛 钟佳鑫 卢金星[2] 邓慧玲[3] 谢群 吴媛[2] Zheng Haoran;Bai Lulu;Wang Yuanyuan;Zhong Jiaxin;Lu Jinxing;Deng Huiling;Xie Qun;Wu Yuan(Shaanxi University of Traditional Chinese Medicine,Xi'an 712046,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Xi'an Central Hospital,Xi'an 710003,China;School of Public Health,Xiangnan University,Chenzhou 423000,China)

机构地区：[1]陕西中医药大学,西安712046 [2]中国疾病预防控制中心传染病预防控制所,北京102206 [3]西安市中心医院,西安710003 [4]湘南学院公共卫生学院,郴州423000

出　　处：《中华流行病学杂志》2022年第11期1860-1868,共9页Chinese Journal of Epidemiology

基　　金：湖南省教育厅资助项目(18A457)。

摘　　要：产气荚膜梭菌通过产生大量的毒素导致人类和动物患气性坏疽、肠炎和肠毒素血症。目前,已知产气荚膜梭菌可产生20多种毒素和水解酶。不同的毒素类型与特定的疾病类型相关。毒素分型已由毒素基因的分子检测替代了传统的血清分型方法。因此本文围绕产气荚膜梭菌毒素种类、基本特征、致病机制以及与疾病的关系进行系统回顾总结和展望,为后续的毒素分型等快速检测技术的建立、免疫抗原筛选、抗体制备以及相关致病机制研究提供基础。Clostridium perfringens can produce many kinds of toxins and hydrolase,causing gas gangrene,enteritis and enterotoxemia in both human and animals.It is known that C.perfringens can produce more than 20 toxins and hydrolases.The different toxin types are associated with specific disease types.At present,molecular toxin-typing method by PCR has replaced the traditional serological typing method.In this study,we systematically summarize the types,basic characteristics,pathogenic mechanism and the relationship with disease of C.perfringens toxins to provide evidence for the establishment of rapid detection method,immune antigen screening,antibody preparation and research of related pathogenic mechanism.

关 键 词：腹泻 毒素 产气荚膜梭菌 

分 类 号：R446.5[医药卫生—诊断学]