偶氮苯光开关在生物大分子中的应用  

Application of Azobenzene Photo-Switches in Biomacromolecules

作　　者：胡杰 段然 周典 吴笛 HU Jie;DUAN Ran;ZHOU Dian;WU Di(School of Mechanical Engineering,Chengdu University,Chengdu 610106,China;School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China)

机构地区：[1]成都大学机械工程学院,四川成都610106 [2]成都大学食品与生物工程学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2022年第4期351-360,共10页Journal of Chengdu University（Natural Science Edition）

基　　金：国家自然科学基金项目(21808020)。

摘　　要：在相应结合策略的驱动下,偶氮苯以光开关分子的形式在各类生物大分子中得到了深度应用,特别是在多肽与蛋白质的结构与活性变化、核酸调控,以及脂类、多糖复合物的研究上具有独特价值.从近年来所报道的偶氮苯光开关设计出发对其在生物大分子中的应用做了分类综述,总结了偶氮苯光开关当前的发展现状.Driven by corresponding binding strategies,azobenzene has been deeply applied in various biomacromolecules in the form of photo-switch molecules.Especially,it has a unique value in the changes of structure and activity of polypeptide and proteinthe regulation of nucleic acidand the research of lipid and polysaccharide complexes.Based on the design of azobenzene photo-switch reported in recent years,this paper expounds on its application in biomacro-molecules,summarizes the current development status of azobenzene photo-switch,and looks forward to the application prospect of azobenzene photo-switch in chemical biology.

关 键 词：偶氮苯光开关 光致异构化 生物大分子 蛋白质 核酸 

分 类 号：O625.65[理学—有机化学]