1型糖尿病患儿肠道菌群特征及其与糖脂代谢的相关性  

Characteristics of intestinal flora and its relationship with glucose and lipid metabolism in children with type 1 diabetes mellitus

作　　者：邓莉莉[1] 雷晔飞[1] 杨靖[1] 何骁[2] 邝瑞军 Deng Lili;Lei Yefei;Yang Jing;He Xiao;Kuang Ruijun(Department of Pediatrics,North Branch,The First People's Hospital of Chenzhou City,Chenzhou,Hunan 423000,China;Department of Joint Surgery,The First People's Hospital of Chenzhou City,Chenzhou,Hunan 423000,China)

机构地区：[1]郴州市第一人民医院北院儿科,湖南郴州423000 [2]郴州市第一人民医院关节外科,湖南郴州423000

出　　处：《现代科学仪器》2022年第6期55-60,共6页Modern Scientific Instruments

基　　金：湘南学院2020年度校级科研项目(立项编号:2020XJ94)。

摘　　要：目的:观察1型糖尿病(T1DM)患儿肠道菌群特征与糖脂代谢的相关性。方法:选取2021年1月-2021年11月医院收治的45例T1DM并发酮症酸中毒患儿、30例T1DM患儿30例和健康体检儿童,分析其肠道菌群特征及与糖脂代谢的关系。结果:T1DM患儿肠杆菌、肠球菌、D-乳酸与HbA1c、GAD-Ab阳性、IAA阳性、ICA阳性、TC、TG、LDL-C呈正相关(r>0,P<0.05);而拟杆菌、双歧杆菌、乳酸杆菌与上述糖脂代谢指标呈负相关(r<0,P<0.05)。结论:T1DM患儿以有害菌升高、有益菌降低为主要特征,且与糖、脂代谢相关。Objective:To observe the correlation between intestinal flora characteristics and glucose and lipid metabolism in children with type 1 diabetes mellitus(T DM).Methods:45 children with T DM complicated with 11 ketoacidosis,30 children with T DM and 30 healthy children were selected in hospital from January 2021 to November 12021.The characteristics of intestinal flora and its relationship with glucose and lipid metabolism were analyzed.Results:Enterobacter,Enterococcus and D-lactic acid were positively correlated with HbA1c,GAD AB,IAA,ICA,TC,TG and LDL-C in children with T DM(r>0,P<0.05);Bacteroides,Bifidobacterium and Lactobacillus were negatively correlated 1 with the above indexes of glucose and lipid metabolism(r<0,P<0.05).Conclusion:The main characteristics of children with T DM are the increase of harmful bacteria and the decrease of beneficial bacteria,which are correlated with glucose 1 and lipid metabolism.

关 键 词：1型糖尿病 肠道菌群 糖代谢 脂代谢 

分 类 号：R587.1[医药卫生—内分泌]