破伤风类毒素免疫效果评价  

Evaluation of immune effect of tetanus toxoid

作　　者：庄天从 王传林[2] 吕新军[3] Zhuang Tiancong;Wang Chuanlin;Lyu Xinjun(Department of General Practice,Luoshan Street Community Health Service Center of Jinjiang City,Jinjiang 362200,China;National Trauma Medical Center,Emergency Department,People′s Hospital of Peking University,Beijing 100044,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100052,China)

机构地区：[1]晋江市罗山街道社区卫生服务中心全科,晋江362200 [2]北京大学人民医院急诊科国家创伤救治中心,北京100044 [3]中国疾病预防控制中心病毒病预防控制所,北京100052

出　　处：《中华微生物学和免疫学杂志》2022年第11期871-874,共4页Chinese Journal of Microbiology and Immunology

摘　　要：目的了解破伤风类毒素(tetanus toxoid,TT)免疫效果,为改进破伤风免疫预防策略提供参考。方法2019—2021年,对在晋江市罗山街道社区卫生服务中心因外伤就诊的患者调查其含破伤风类毒素疫苗(tetanus toxoid-containing vaccine,TTCV)免疫史。对353例TTCV计划免疫后5~10年的受试者(A组)检测血清破伤风抗体(tetanus antibody,TAB),比较不同年龄人群不同TAB水平(<0.01 IU/ml、0.01~0.10 IU/ml、>0.10 IU/ml)受试者的分布差异;对68例有TTCV免疫史、年龄14~83岁、TAB水平为0.01~0.10 IU/ml的受试者(B组)与133例无TTCV免疫史、年龄17~77岁的受试者(C组)分别接种1剂、3剂TT,观察免疫后28 d TAB水平变化。结果A组不同年龄人群不同TAB水平的受试者比例差异有统计学意义(χ^(2)=47.69,P<0.001),随着年龄增长,TAB水平在<0.01 IU/ml和0.01~0.10 IU/ml之间的受试者比例增高。B组受试者1剂TT免疫后28 d,68例中有66例TAB>0.10 IU/ml,免疫前后TAB水平为0.01~0.10 IU/ml、>0.10 IU/ml的受试者比例差异有统计学意义(χ^(2)=128.23,P<0.001)。C组受试者3剂TT免疫前,133例中有129例TAB<0.01 IU/ml、4例TAB为0.01~0.10 IU/ml;3剂TT免疫后28 d,1例TAB为0.01~0.10 IU/ml、132例TAB>0.10 IU/ml,免疫前后不同TAB水平的受试者比例差异有统计学意义(χ^(2)=262.80,P<0.001)。结论TTCV计划免疫5年后,TAB水平在<0.01 IU/ml和0.01~0.10 IU/ml之间的个体比例随年龄增长而增高;对于无TTCV免疫史人群和TTCV免疫后TAB保护作用下降的人群,加强TT免疫可以显著提高群体TAB保护状况。Objective To analyze the immune effect of tetanus toxoid(TT)and to provide reference for improving immunoprophylaxis strategies against tetanus.Methods From 2019 to 2021,the TT-containing vaccine(TTCV)immunization history of patients treated for trauma in Luoshan Street Community Health Service Center of Jinjiang City were investigated.Serum tetanus antibody(TAB)levels were detected in 353 subjects(group A)5-10 years after TTCV immunization,and the proportions of subjects with different TAB levels(<0.01 IU/ml,0.01-0.10 IU/ml,>0.10 IU/ml)in different age groups were compared.Sixty-eight subjects(group B)aged 14-83 years with TTCV immunization history and TAB level of 0.01-0.10 IU/ml and 133 subjects(group C)aged 17-77 years without TTCV immunization history were inoculated with one dose and three doses of TT respectively,and the changes in TAB level were observed 28 d after immunization.Results In group A,the proportions of subjects with different TAB levels in different age groups were statistically significant(χ^(2)=47.69,P<0.001).The proportions of subjects in which TAB levels were<0.01 IU/ml and 0.01-0.10 IU/ml increased with age.In group B,66 out of the 68 subjects had TAB>0.10 IU/ml 28 d after one dose of TT immunization.There were statistically significant differences in the proportions of subjects whose TAB levels were 0.01-0.10 IU/ml and>0.10 IU/ml before and after TT immunization(χ^(2)=128.23,P<0.001).In group C,before three doses of TT immunization,129 patients had TAB<0.01 IU/ml and four patients had TAB in the range of 0.01-0.10 IU/ml;28 d after three doses of TT immunization,only one case had TAB in the range of 0.01-0.10 IU/ml and 132 cases had TAB>0.10 IU/ml.The proportions of group C subjects with different TAB levels before and after TT immunization were statistically significant(χ^(2)=262.80,P<0.001).Conclusions Five years after TTCV immunization,the proportions of individuals with TAB<0.01 IU/ml and in the range of 0.01-0.10 IU/ml increased with age.For people without TTCV immunization histo

关 键 词：破伤风 含破伤风类毒素疫苗 破伤风类毒素 破伤风抗体 

分 类 号：R392[医药卫生—免疫学]