MicroRNA在自身免疫性肝病中的研究进展  

Research progress in the role of microRNA in autoimmune liver diseases

作　　者：徐运活 李海侠[1] XU Yunhuo;LI Haixia(Department of Clinical Laboratory,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院检验科,广州510515

出　　处：《免疫学杂志》2022年第12期1100-1104,共5页Immunological Journal

基　　金：国家自然科学基金青年项目(82002218);广东省自然科学基金面上项目(2019A1515010103);南方医科大学南方医院院长基金(2019Z016)。

摘　　要：MicroRNA(miRNA)是一类由内源基因编码的长度约为18~25个核苷酸的非编码单链RNA分子,在细胞内参与多种调节作用,并参与细胞转录后的基因表达调控和炎症反应等多种生物学过程。近年来的研究发现,多种miRNA在自身免疫性肝病(autoimmune liver disease,AILD)中存在差异表达,具有良好的诊断和治疗价值。本文旨在结合自身免疫性肝炎、原发性胆汁性胆管炎、原发性硬化性胆管炎等疾病,阐述microRNA在这些自身免疫性肝病中的最新研究进展,以期为疾病的诊断和治疗提供新的依据。MicroRNA(miRNA)is a class of non-coding single-stranded RNA molecules encoded by endogenous genes with a length of about 18~25 nucleotides,which is involved in a variety of regulatory effects in cells,as well as the regulation of gene expression after cell transcription and a variety of biological processes of inflammatory response.Recent studies have found that various miRNA are differentially expressed in autoimmune liver disease(AILD),which has good diagnostic and therapeutic value.Based on recent research reports,this paper reviews the new progress of microRNA in autoimmune liver disease.

关 键 词：MICRORNA 自身免疫性肝病 自身免疫性肝炎 原发性胆汁性胆管炎 原发性硬化性胆管炎 

分 类 号：R392.11[医药卫生—免疫学]