儿童合理应用口服H_(1)抗组胺药的临床实践指南(2022年版)  

Clinical practice guideline for the rational use of oral H_(1)-antihistamines in children(2022 edition)

作　　者：周鹏翔[1,2] 周薇 申昆玲[4] 洪建国[5] 詹思延[6] 翟所迪[1,2] 赵京[7] 王良录 中华医学会变态反应分会[9] 中国医药教育协会儿科专业委员会[9] 中国妇幼保健协会药事管理专业委员会 亚太生物免疫学会儿童过敏免疫风湿病分会 ZHOU Pengxiang;ZHOU Wei;SHEN Kunling;HONG Jianguo;ZHAN Siyan;ZHAI Suodi;ZHAO Jing;WANG Lianglu;on behalf of Chinese Society of Allergy;Committee on Pediatrics of China Medicine Education Association;Committee on Pharmacy Administration of China Maternal and Child Health Association;Pediatric Allergy,Immunology and Rheumatology Branch of Asia-Pacific Association of Medicineand Bio-immunology(Department of Pharmacy,Peking University Third Hospital,Beijing 100191,P.R.China;Institute for Drug Evaluation,Peking University Health Science Center,Beijing 100191,P.R.China;Department of Pediatrics,Peking University Third Hospital,Beijing 100191,P.R.China;National Center for Children’s Health,Department of Respiratory,Beijing Children’s Hospital,Capital Medical University,National Clinical Research Center for Respiratory Disease,Beijing 100045,P.R.China;Department of Pediatrics,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,P.R.China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,P.R.China;Department of Allergy,Children’s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,P.R.China;Department of Allergy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,P.R.China;不详)

机构地区：[1]北京大学第三医院药剂科,北京100191 [2]北京大学医学部药物评价中心,北京100191 [3]北京大学第三医院儿科,北京100191 [4]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京100045 [5]上海交通大学附属第一人民医院儿内科,上海200127 [6]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [7]首都儿科研究所附属儿童医院变态反应科,北京100020 [8]北京协和医院变态反应科,中国医学科学院北京协和医学院,北京100730 [9]不详

出　　处：《中国循证医学杂志》2022年第12期1365-1374,共10页Chinese Journal of Evidence-based Medicine

基　　金：国家科技重大专项项目(编号:2017ZX09304029-005-02);国家自然科学基金项目(编号:81872939)。

摘　　要：口服H_(1)抗组胺药是儿童变态反应性疾病治疗中最常用的药物类别之一,但其合理应用仍缺乏充分的证据支持及药学指导,因此临床应用存在一定风险。本指南制订工作组基于当前最佳证据、专家经验和患儿家属意愿,采用证据推荐分级评估、制订与评价方法(GRADE),制订《儿童合理应用口服H_(1)抗组胺药的临床实践指南》。指南最终形成了8个方面的19条推荐意见,涵盖口服H_(1)抗组胺药在儿童变态反应性疾病中的治疗地位、年龄范围、剂量、疗程、肝肾功能不全时的方案调整、相互作用、不良反应和依从性等内容,用于规范和指导口服H_(1)抗组胺药在儿童变态反应性疾病中的合理应用。Oral H_(1)-antihistamines are one of the most commonly prescribed drug categories in the treatment of allergic diseases in children.However,its rational application still lacks sufficient evidence and pharmaceutical guidance,making its clinical use risky.Based on the best available evidence,expert experience,and the willingness of patients'families,the guideline development panel developed this guideline,using the grading of recommendations assessment,development and evaluation(GRADE)approach.The guidelines developed 19 recommendations in 8 domains,covering the therapeutic status of oral H_(1)-antihistamines in pediatric allergic diseases,age range,dose,duration of treatment,adjustment in the presence of hepatic and renal insufficiency,drug interactions,adverse effects and adherence.As a result,this guideline helped to standardize and guide the rational use of oral H_(1)-antihistamines in pediatric allergic diseases.

关 键 词：H_(1)抗组胺药 儿童 变态反应性疾病 临床实践指南 

分 类 号：R969.3[医药卫生—药理学]