核小体重塑与去乙酰化酶复合物在γ珠蛋白调控中作用的研究进展  

Research progress on roles of nucleosome remodeling and deacetylase complex in regulation ofγglobin

作　　者：李静[1] 赖永榕[1] Li Jing;Lai Yongrong(Department of Hematology,First Affiliated Hospital of Guangxi Medical University,Nanning 53000,Guangxi Province,China)

机构地区：[1]广西医科大学第一附属医院血液科,南宁530000

出　　处：《国际输血及血液学杂志》2022年第5期449-454,共6页International Journal of Blood Transfusion and Hematology

摘　　要：核小体重塑与去乙酰化酶(NuRD)复合物是同时具有组蛋白去乙酰化和染色质重塑活性的独特复合物, 在转录调节和DNA损伤修复过程中发挥重要功能。近年研究发现, NuRD复合物在γ珠蛋白的调控中, 亦发挥重要作用。NuRD复合物中的多个亚基, 如染色质螺旋酶DNA结合蛋白(CHD)、甲基化CpG结合蛋白(MBD)、GATA锌指结合域蛋白(GATAD)2、组蛋白去乙酰化酶(HDAC)1/2, 以及转移相关蛋白(MTA)亚基等, 通过不同机制参与沉默γ珠蛋白表达, 并且NuRD复合物与其他调控γ珠蛋白表达的转录因子之间亦有相互作用。基于提升γ珠蛋白的表达是治疗β血红蛋白病的策略之一, 笔者拟就NuRD复合物及其亚基在γ珠蛋白表达调控中的具体机制的研究进展进行综述, 旨在为治疗β血红蛋白病寻找新的分子调控靶点提供参考。Nucleosome remodeling and deacetylase(NuRD)complex is unique in that it couples histone deacetylation and chromatin remodeling activities in the same complex.NuRD complex plays essential roles in regulating transcription and repairing damaged DNA.NuRD complex also has impact onγglobin expression demonstrated by recent researches.Several subunits,such as chromodomain helicase DNA-binding protein(CHD),methyl-CpG binding protein(MBD),GATA zinc finger domain containing protein(GATAD),histone deacetylase(HDAC),metastasis associated protein(MTA),in NuRD complex participate in silencingγglobin expression through different mechanisms,and NuRD complex also interacts with other transcription factors that regulateγglobin expression.Based on promotion ofγglobin expression is one of therapeutic strategies forβhemoglobinopathy,the recent research progress on mechanisms of regulatingγglobin in NuRD complex and its subunits will be interpreted in this review,for the purpose of exploring potential regulatory targets for treatingβhemoglobinopathy.

关 键 词：核小体 Mi-2核小体重塑与去乙酰化酶复合物 珠蛋白类 基因表达调控 Β地中海贫血 贫血 镰状细胞性 

分 类 号：R346[医药卫生—基础医学]