2016-2020年河南省平顶山市97例HIV抗体不确定样本的首次检测和随访结果  

The first detection and follow-up results for 97 samples with uncertain HIV antibody in Pingdingshan of Henan,2016-2020

作　　者：石朝辉[1] 刘春华[2] 杨艳华 郑艳丽[1] 余冰倩 SHI Zhaohui;LIU Chunhua;YANG Yanhua;ZHENG Yanli;YU Bingqian(STD and AIDS Prevention and Control Program,Pingdingshan Center for Disease Control and Prevention,Pingdingshan,Henan 467000,China,2.Henan Center for Disease Control and Prevention)

机构地区：[1]平顶山市疾病预防控制中心性病艾滋病预防控制科,河南平顶山467000 [2]河南省疾病预防控制中心

出　　处：《河南预防医学杂志》2022年第11期864-867,共4页Henan Journal of Preventive Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20190712)。

摘　　要：目的分析97例人类免疫缺陷病毒(human immunodeficiency virus,HIV)抗体不确定样本的首次检测和随访结果,探讨HIV抗体不确定样本的转归规律。方法选取2016-2020年平顶山市疾病预防控制中心艾滋病确证实验室检测的97例HIV抗体不确定病例为研究对象,分析其一般信息、发现途径、免疫印迹(western blot,WB)带型,将不确定样本按照WB条带数量和S/CO值大小各分三组,分析六组间的首次病毒载量(viral load,VL)和WB实验随访结果。结果97例样本中,带型最多的是一条带,以p24单条带数量最多(25例,37.88%),其次是两条带,其中以gp160+P24为最常见(15例,22.73%)。按照不确定样本的WB带型所分的三组间随访结果阳转率有统计学意义(χ^(2)=11.789,P<0.05),三条带及以上组阳转率最高;按照S/CO值划分的三组间随访结果阳转率有统计学意义(χ^(2)=12.684,P<0.05),S/CO≥6.0组阳转率最高;各组的VL检测结果与最终的WB实验阳转结果基本一致。结论HIV抗体不确定样本在首次检测和随访结果中,初次检测条带越多,阳转率越高;S/CO越高,阳转率越高。核酸检测结果和最终WB阳转结果基本一致。Objective To analyze the first detection and follow-up results for 97 samples with uncertain human immunodeficiency virus(HIV)antibody,and explore the outcome of HIV antibody uncertain samples.Methods A total of 97 cases of HIV with uncertain antibody detected in the AIDS Confirmation Laboratory,Pingdingshan Center for Disease Control and Prevention from2016 to 2020 were selected as the study objects.The general information,discovery pathway and Western blot(WB)band type of the cases were analyzed.The uncertain samples were divided into three groups according to the number of WB bands and S/CO value,respectively.The initial viral load(VL)and WB test follow-up results were analyzed among the six groups.Results Of the97 samples,one band was most common,and P24 was the most common(25 cases,37.88%),followed by two bands,of which GP160+P24 was most common(15 cases,22.73%).The positive conversion rate was statistically significant among the three groups according to the WB band type of the uncertain samples(χ^(2)=11.789,P<0.05),and the positive conversion rate was highest in the group with three or more WB bands.The follow-up results showed that the positive conversion rate was statistically signif-icant among the three groups according to S/CO value(χ^(2)=12.684,P<0.05),and the positive rate was highest in S/CO≥6.0 group.The VL test results of each group were basically consistent with the final WB test positive conversion results.Conclusion In the initial detection and follow-up results of the uncertain HIV antibody samples,the more bands the initial detection has,the higher the positive conversion rate is and the higher the S/CO,the higher the positive conversion rate.The result of nucleic acid test is basically consistent with the final WB positive transformation result.

关 键 词：HIV抗体不确定 随访 WB带型 阳转率 病毒载量 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]