Optically Active Nucleobase-Functionalized Polynorbornenes Mimicking Double-Helix DNA  

作　　者：Li Wang Nan Lu Shuai Huang Meng Wang Xu-Man Chen Hong Yang 

机构地区：[1]School of Chemistry and Chemical Engineering,Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research,Institute of Advanced Materials,Southeast University,Nanjing 211189 [2]College of Chemistry and Material Science,Shandong Agricultural University,Taian 271018

出　　处：《CCS Chemistry》2021年第6期1787-1796,共10页中国化学会会刊（英文）

基　　金：The authors thank the National Natural Science Foundation of China(grant no.21971037);the Jiangsu Provincial Natural Science Foundation of China(grant no.BK20170024)for the support of this research project.

摘　　要：The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science.In this study,we designed and synthesized two chiral norbornene monomers containing adenine and thymine,which were mixed to form a hydrogen-bonding complementary complex,by which a ring-opening metathesis polymerization(ROMP)was performed.High-resolution transmission electron microscopy(HRTEM)undoubtedly showed the self-assembly of the optically active complementary nucleobasefunctionalized polynorbornenes into a double helix.Computer simulations and a two-dimensional nuclear Overhauser effect spectroscopy(2DNOESY)experiment showed that the doublestranded helical polynorbornene was derived from a copolymer of alternating adenine and thymine units.

关 键 词：POLYNORBORNENE CHIRALITY NUCLEOBASE hydrogen bond double helix 

分 类 号：O63[理学—高分子化学]