Logic-Gated Plasmonic Nanodevices Based on DNA-Templated Assembly  

作　　者：Fengsong Liu Qiao Jiang Qing Liu Na Li Zihong Han Chao Liu Zhaoran Wang Yunfei Jiao Jiashu Sun Baoquan Ding 

机构地区：[1]CAS Key Laboratory of Nanosystem and Hierarchical Fabrication,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190 [2]University of Chinese Academy of Sciences,Beijing 100049 [3]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450001

出　　处：《CCS Chemistry》2021年第3期985-993,共9页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(31700871,21773044,51761145044,and 21721002);the National Basic Research Program of China(2016YFA0201601 and 2018YFA0208900);Beijing Municipal Science&Technology Commission(Z191100004819008);Key Research Program of Frontier Sciences,CAS,grant QYZDBSSW-SLH029;the Strategic Priority Research Program of Chinese Academy of Sciences(XDB36000000);CAS Interdisciplinary Innovation Team;K.C.Wong Education Foundation(GJTD-2018-03).

摘　　要：Life has evolved numerous elegant molecular machines that recognize biological signals and affect mechanical changes precisely to achieve specific and versatile biofunctions.Inspired by nature,synthetic molecular machines could be designed rationally to realize nanomechanical operations and autonomous computing.We constructed logic-gated plasmonic nanodevices through coassembly of two gold nanorods(AuNRs)and computing elements on a tweezer-shaped DNA origami template.After recognition of various molecular inputs,such as DNA strands,glutathione,or adenosine,the geometry and plasmonic circular dichroism(CD)signals of the AuNR–origami nanodevices produced corresponding changes.Then we designed and characterized a set of modular Boolean logic-gated nanodevices(YES,NOT,AND,OR)and proceeded to construct a complicated 3-input circuit capable of performing Boolean OR-NOT-AND operations.Our plasmonic logic devices transduced external inputs into conformational changes and near-infrared(NIR)chiral outputs.This DNA-based self-assembly strategy holds great potential for applications in programmable optical modulators,molecular information processing,and bioanalysis.

关 键 词：DNA origami self-assembly logic gate chiral plasmonic nanostructure DNA computing 

分 类 号：TB383[一般工业技术—材料科学与工程]