Twisted Intramolecular Charge Transfer—Aggregation-Induced Emission Fluorogen with Polymer Encapsulation-Enhanced NearInfrared Emission for Bioimaging  

作　　者：Lingchen Meng Xibo Ma Shan Jiang Song Zhang Zhiyuan Wu Bin Xu Zhen Lei Leijing Liu Wenjing Tian 

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials,Department of Chemistry,Jilin University,Changchun 130012 [2]CBSR&NLPR,Institute of Automation,Chinese Academy of Sciences,Beijing 100049 [3]School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049

出　　处：《CCS Chemistry》2021年第3期2084-2094,共11页中国化学会会刊（英文）

基　　金：supported by the National Natural Science Foundation of China(nos.21835001,51773080,and 21674041);Program for Changbaishan Scholars of Jilin Province,and the“Talents Cultivation Program”of Jilin University。

摘　　要：Fluorescence probes with strong near-infrared(NIR)emission and water solubility are considered useful visualization tools for localization marking as well as investigating cell migration and transplantation.Here,we designed and synthesized a new donor–π–acceptor(D–π–A)fluorogen,2-(4-[(E)-4-(diphenylamino)styryl]phenyl)-3-(4′-[1,2,2-triphenylvinyl]-[1,1′-biphenyl]-4-yl)fumaronitrile(TB-TPE).TB-TPE exhibits twisted intramolecular charge transfer(TICT)and aggregation-induced emission(AIE)in the NIR region,with an emission peak at 714 nm and a fluorescence quantum yield(Qy)of 6.6%in the solid state.By encapsulating TB-TPE with polystyrene–polyethylene glycol(PS-PEG),watersoluble TB-TPE-PS-PEG nanoparticles(TP NPs)are fabricated,which display polymer encapsulationenhanced emission with a Qy of 46.5%due to the strong restriction effect on the TICT process and the destruction of H aggregation for TB-TPE by the polymer matrix.Au-coated Fe_(3)O_(4)(Fe_(3)O_(4)@Au)nanocrystals were then embedded in the TP NPs to form highly fluorescent TB-TPE-Fe_(3)O_(4)-Au-PS-PEG nanoparticles(TFAP NPs)with a Qy of 39.7%.Our demonstration of successful cellular imaging of TP NPs for Hep-G2 cells and multimodality imaging of TFAP NPs in mouse liver tumors indicates that polymer-encapsulated TB-TPE offers great prospects as a multifunctional fluorescence probe for bioimaging.

关 键 词：AIE TICT NIR polymer encapsulationenhanced emission BIOIMAGING 

分 类 号：O62[理学—有机化学]