葛根素温敏分子印迹聚合物的制备及其吸附性能  

Preparation and adsorption properties of puerarin thermal-sensitive molecularly imprinted polymers

作　　者：黄金梅 钟海艺 杨舒悦 黄凤玲 HUANG Jin-mei;ZHONG Hai-yi;YANG Shu-yue;HUANG Feng-ling(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200

出　　处：《陕西科技大学学报》2023年第1期59-65,共7页Journal of Shaanxi University of Science & Technology

基　　金：广西壮族自治区自然科学基金项目(2019GXNSFBA245088);广西中医药大学引进博士科研启动基金项目(2017BS034);广西中医药大学校级科研项目(2018QN006)。

摘　　要：以葛根素为模板分子,丙烯酰胺(AM)为功能单体,N-异丙基丙烯酰胺(NIPAM)为温敏单体,乙二醇二甲基丙烯酸酯(EGDMA)为交联剂,采用沉淀聚合法制备葛根素温敏分子印迹聚合物(MIP2).静态吸附研究表明,所得分子印迹材料能有效地对葛根素进行选择性吸附,当吸附液浓度为1 mg/mL时,MIP2的吸附量可达45.51 mg/g,吸附过程符合Langmuir模型的表面单层分子吸附,且材料对温度具有一定的响应性,在低温条件下(30℃)具有更高的吸附量.该研究可为天然药物中异黄酮类葛根素成分的分离纯化、富集提供新的方法与思路.Puerarin thermal-sensitive molecularly imprinted polymers(MIP2)were synthesized by precipitation polymerization which containing puerarin as templates,acrylamide(AM)as functional monomers,N-isopropylacrylamide(NIPAM)as temperature sensitive monomer and ethylene glycol dimethacrylate(EGDMA)as crosslinkers.Static adsorption demonstrated that these imprinted polymers possessed well specific adsorption properties for puerarin,the adsorbing capacity reached 45.51 mg/g when concentration of quercetin was 1 mg/mL for MIP2,and the adsorption process accorded with Langmuir model.The MIP2 exhibits temperature responsive behavior,which had a higher adsorption capacity at low temperature(30℃).This study can provide some new thoughts and methods to separate and purify puerarin from natural medicines.

关 键 词：分子印迹聚合物 葛根素 温敏 吸附 

分 类 号：O631.1[理学—高分子化学]