盐酸安妥沙星治疗慢性细菌性前列腺炎效果分析  

Therapeutic effects of antofloxacin hydrochloride on chronic bacterial prostatitis

作　　者：李健 熊杰 王英宝 龚瑞 张鹤云 LI Jian;XIONG Jie;WANG Yingbao(Department of Urology,Yan’an Hospital,Yunnan,Kunming 650051,China)

机构地区：[1]昆明市延安医院泌尿外科,云南省650051

出　　处：《河北医药》2022年第22期3462-3464,共3页Hebei Medical Journal

摘　　要：目的探究盐酸安妥沙星治疗慢性细菌性前列腺炎疗效。方法选取2017年10月至2019年10月门诊收治的慢性细菌性前列腺炎患者250例为研究对象,采用区组随机方法分为A组(安妥沙星治疗)和B组(左氧氟沙星治疗)。观察2组患者基线资料、治疗后1周有效率、症状改善情况、白细胞计数、前列腺液(EPS)中炎性因子表达情况及安全性。结果A组患者治疗后1周总有效率显著高于B组,差异有统计学意义(χ^(2)=7.148,P=0.008);2组患者治疗后CPSI评分显著升高,白细胞计数显著降低,且A组治疗后各指标显著优于B组,差异有统计学意义(P<0.05);2组患者治疗后EPS中IL-1、IL-6和TNF-α均显著降低,且A组治疗后各指标显著优于B组,差异有统计学意义(P<0.05);A组患者治疗后发生头晕头痛1例,发热1例,恶心呕吐1例,停药后症状消失;B组患者治疗后头晕头痛1例,发热2例,恶心呕吐0例,停药后症状缓解。结论盐酸安妥沙星与左氧氟沙星相比,治疗细菌性前列腺炎疗效更佳,有助于改善症状、白细胞数和EPS中炎性因子表达量,安全可靠。Objective To investigate the therapeutic effects of antofloxacin hydrochloride on chronic bacterial prostatitis.Methods A total of 250 patients with chronic bacterial prostatitis who were treated in our hospital from October 2017 to October 2020 were enrolled in the study,who were randomly divided into group A(antofloxacin treatment)and group B(levofloxacin treatment).The baseline data,the effective rate after 1-week treatment,and the improvement status of symptoms,white blood cell count,the expression levels of inflammatory factors in prostate fluid(EPS)were observed and compared between the two groups.Results After 1-week treatment,the total effective rate in group A was 94.3%,which was significantly higher than that(83.6%)in group B signify(P<0.01).And the CPSI scores in both groups were increased significantly,however,the white blood cell count was significant decreased,and the indexes in group A were superior to those in group B(P<0.05).After treatment the levels of IL-1,IL-6 and TNF-αin EPS in both groups were significantly decreased,moreover,which in group A were superior to those in group B(P<0.05).After treatment,there was 1 case of dizziness,1 case of headache,1 case of fever and nausea and vomiting in group A,and the symptoms disappeared after treatment,and there was 1 case of dizziness and headache,2 cases of fever in group B,and the symptoms were relieved after treatment.Conclusion Compared with levofloxacin,the antofloxacin hydrochloride has better therapeutic effects on chronic bacterial prostatitis,which is helpful for improving the symptoms,white blood cell count and the expression of inflammatory factors in EPS,with safety and reliability.

关 键 词：盐酸安妥沙星 左氧氟沙星 慢性细菌性前列腺炎 疗效分析 

分 类 号：R697.33[医药卫生—泌尿科学]