苗医弩药针联合金骨莲胶囊治疗老年膝关节炎的疗效  

Effect of Miao medical crossbow medicine needle combined with Jingulian capsule in the treatment of knee osteoarthritis

作　　者：肖淦辰 熊芳丽 蒲健 杨华 方志聪 吕岑 赵英涛 XIAO Gan-Chen;XIONG Fang-Li;PU Jian(The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,Guizhou,China)

机构地区：[1]贵州中医药大学第一临床医学院,贵州贵阳550001 [2]贵州益佰制药股份有限公司 [3]贵州中医药大学研究生院

出　　处：《中国老年学杂志》2023年第2期337-341,共5页Chinese Journal of Gerontology

基　　金：科技部国家重点研发计划中医药现代化研究项目(2019YFC1712501);“十二五”国家科技支撑计划课题(2012BAI27B04-12);国家中医药管理局重点研究室建设项目(国中医药函【2009】95号);国家中医药管理局委托办事项目(GZY-FJS-201-53)。

摘　　要：目的 探讨分析苗医弩药针联合金骨莲胶囊治疗老年膝关节炎(KOA)的应用效果。方法 选取90例老年KOA患者,依据随机数字表法分为A组、B组和C组,各30例。A组实施单纯西药治疗,B组实施苗医弩药针+金骨莲胶囊治疗,C组实施西药+苗医弩药针+金骨莲胶囊治疗,均治疗8 w。分别于治疗前、治疗8 w时,使用视觉模拟评分(VAS)、Lysholm膝关节评分量表(LKSS)和骨关节炎指数评分(WOMAC)评估3组的疼痛程度和膝关节功能情况;各时点,检测并对比3组的炎症因子[白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α]和环氧合酶(COX)-2水平;各时点,评估3组步态参数;记录3组治疗期间的不良反应发生情况。结果 治疗8 w时,3组VAS、WOMAC评分均较治疗前降低,LKSS评分较治疗前升高,且C组VAS、WOMAC评分低于A组和B组,LKSS评分高于A组和B组,差异有统计学意义(P<0.05);A组和B组的VAS、WOMAC及LKSS评分对比,差异无统计学意义(P>0.05);治疗8 w时,3组的IL-1β、TNF-α及COX-2水平均较治疗前降低,且C组低于A组和B组,差异有统计学意义(P<0.05);A组和B组IL-1β、TNF-α及COX-2水平对比,差异无统计学意义(P>0.05);治疗8 w时,3组步长、步速均较治疗前升高,且C组高于A组和B组,差异有统计学意义(P<0.05);A组和B组步长、步速对比,差异无统计学意义(P>0.05);治疗期间,3组总不良反应发生率对比,差异无统计学意义(P>0.05)。结论 苗医弩药针联合金骨莲胶囊更利于减轻老年KOA患者疼痛感和炎症反应,提高膝关节功能,改善步态特征且安全性好。Objective To investigate and analyze the effect of Miao medical crossbow medicine needle combined with Jingulian capsule in the treatment of elderly knee osteoarthritis(KOA).Methods 90 elderly patients with KOA were randomly divided into group A, group B and group C with 30 cases in each groups.Group A was treated with western medicine alone, and group B was treated with Miao medical crossbow medicine needle and Jingulian capsule.Group C was treated with western medicine and Miao medical crossbow medicine needle and Jingulian capsule.All three groups were treated for 8 weeks.The pain degree and knee function of the three groups were evaluated by visual analogue scale(VAS), Lysholm knee joint scale(LKSS) and osteoarthritis index score(WOMAC) before treatment and at 8 weeks of treatment respectively.At each time point, the levels of inflammatory factors [interleukin(IL)-1β, tumor necrosis factor(TNF)-α] and cyclooxygenase(COX)-2 in the three groups were detected and compared.Three groups of gait parameters at each time point were evaluated.The adverse reactions of three groups during treatment were recorded.Results At the 8th week of treatment, VAS and WOMAC scores in three groups were lower than those before treatment, and LKSS score was higher than that before treatment.In group C, VAS and WOMAC scores were lower than those in group A and group B, and LKSS score was higher than that in group A and group B, with a statistical significant difference(P<0.05).There was no statistical significant difference in VAS, WOMAC and LKSS scores between group A and group B(P>0.05).At the 8th week of treatment, the levels of IL-1β, TNF-α and COX-2 in three groups were lower than those before treatment, and the levels in group C were lower than those in group A and group B, with a statistical significant difference(P<0.05).There was no statistical significant difference in the levels of IL-1β, TNF-α and COX-2 between group A and group B(P>0.05).At the 8th week of treatment, the step length and pace of three groups were hig

关 键 词：膝关节炎 金骨莲胶囊 苗医弩药针 疼痛程度 膝关节功能 

分 类 号：R684.3[医药卫生—骨科学]