西洛他唑联合阿司匹林对颈动脉内膜剥脱术后患者血小板功能及炎性因子的影响  

Effect of Cilostazol Combined with Aspirin on Platelet Function and Inflammatory Factors in Patients Underwent Carotid Endarterectomy

作　　者：李山峰[1] 王翠 赵峰[1] 何运良[1] 鄂亚军[1] LI Shanfeng;WANG Cui;ZHAO Feng;HE Yunliang;E Yajun(Affiliated Hospital of Hebei University,Baoding,Hebei,China 071000;The First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China 050030)

机构地区：[1]河北大学附属医院,河北保定071000 [2]河北医科大学第一医院,河北石家庄050030

出　　处：《中国药业》2023年第1期96-99,共4页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题项目[20220391]。

摘　　要：目的探讨西洛他唑联合阿司匹林治疗颈动脉内膜剥脱术后颈动脉狭窄的临床疗效,以及对患者血小板功能及炎性因子水平的影响。方法选取河北大学附属医院2018年11月至2021年11月收治的颈动脉狭窄患者96例,按随机抽签法分为观察组和对照组,各48例。两组患者均予颈动脉内膜剥脱术治疗,术后口服阿司匹林,观察组患者在此基础上加用西洛他唑,均以4周为1个疗程,连续治疗3个疗程。结果观察组总有效率为91.67%,显著高于对照组的72.92%(P<0.05)。治疗后,观察组患者的美国国立卫生研究院卒中量表(NIHSS)评分显著低于对照组,蒙特利尔认知评估量表(MoCA)和简易智力状态检查量表(MMSE)评分均显著高于对照组(P<0.05);观察组患者的平均血小板体积(MPV)、血小板聚集率(PAgT)、血小板反应蛋白1(THBS-1)均显著低于对照组(P<0.05);观察组患者的炎性因子指标包括细胞间黏附分子-1(ICAM-1)、血清可溶性血凝素样氧化低密度脂蛋白受体1(sLOX-1)的水平均显著低于对照组(P<0.05)。观察组和对照组患者治疗期间不良反应发生率相当(16.67%比10.42%,P>0.05)。结论西洛他唑联合阿司匹林可提高颈动脉内膜剥脱术后颈动脉狭窄患者的临床疗效,改善患者颅神经损伤程度,调节血小板功能,抑制炎性因子表达,且治疗安全性良好。Objective To investigate the clinical efficacy of cilostazol combined with aspirin in the treatment of carotid stenosis in patients underwent the carotid endarterectomy,and its effect on the platelet function and inflammatory factor levels of patients.Methods A total of 96 patients with stenosis admitted to the Affiliated Hospital of Hebei University from November 2018 to November 2021 were selected and divided into the observation group and the control group by the random lottery method,with 48 cases in each group.The patients in the two groups all underwent the carotid endarterectomy,and took aspirin after the operation,on this basis,the patients in the observation group took cilostazol.Both groups were treated continuously for three courses with four weeks as a course of treatment.Results The total effective rate in the observation group was 91.67%,which was significantly higher than 72.92%in the control group(P<0.05).After treatment,the National Institute of Health Stroke Scale(NIHSS)score in the observation group was significantly lower than that in the control group,and the scores of Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE)in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the mean platelet volume(MPV),platelet aggregation rate(PAgT)and thrombospondin-1(THBS-1)in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of inflammatory factors including intercellular adhesion molecule-1(ICAM-1)and serum soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1)in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group during treatment(16.67%vs.10.42%,P>0.05).Conclusion Cilostazole combined with aspirin is effective and safe in the treatment of carotid stenosis in patients underwent the carotid endarterectomy,which can imp

关 键 词：西洛他唑 阿司匹林 颈动脉狭窄 颈动脉内膜剥脱术 颅神经损伤 血小板功能 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R973.2[医药卫生—药学]