噪声性听力损失与血白细胞计数的相关性研究  

Study on the correlation between noise-induced hearing loss and white blood cell count

作　　者：卢映君[1] 张维森 周浩[1] 肖吕武[1] 周海林[1] Lu Yingjun;Zhang Weisen;Zhou Hao;Xiao Lyuwu;Zhou Hailin(Occupational Health Management Department,Guangzhou Twelfth People's Hospital,Guangzhou Occupational Disease Prevention and Control Institute,Guangzhou 510620,China)

机构地区：[1]广州市第十二人民医院,广州市职业病防治院职业卫生管理科,广州510620

出　　处：《国际医药卫生导报》2023年第1期115-118,共4页International Medicine and Health Guidance News

摘　　要：目的分析噪声性听力损失与血白细胞计数的关联性,以期为职业性噪声性健康损害提供新的人群研究证据。方法2009年委托广州市职业病防治院开展职业健康检查的工厂157家,噪声作业工人14396名,结合职业健康检查,选择其中同时检查血常规、空腹血糖、血脂和纯音听力的噪声作业人员3508人为研究对象,其中男2969人,女539人。同时调查收集其一般信息、职业接触史、听觉系统疾病史等资料。噪声性听力损失与白细胞计数的相关性分别采用t检验和协方差分析,与白细胞偏高的相关性采用logistic回归分析。结果两独立样本t检验和调整性别、年龄、接噪工龄、空腹血糖、总胆固醇和三酰甘油后的协方差分析结果均提示,噪声性听力损失组白细胞计数均高于听力正常组[(7.15±0.06)×10^(9)/L比(6.91±0.03)×10^(9)/L、(6.94±0.07)×10^(9)/L比(6.79±0.04)×10^(9)/L],差异均有统计学意义(t=-3.912、P<0.001,F=5.618、P=0.018);调整性别、年龄、接噪工龄、空腹血糖、总胆固醇和三酰甘油后,logistic回归分析结果显示,相对于听力正常组,噪声性听力损失组白细胞偏高风险增加32%,比值比为1.32(95%可信区间:1.03~1.70,P<0.05)。结论噪声性听力损失与白细胞计数升高独立相关,提示噪声暴露可能诱发机体出现慢性炎性反应。Objective To analyze the correlation between noise-induced hearing loss(NIHL)and white blood cell count(WBC),so as to provide new population study evidences for occupational noise health damage.Methods In 2009,Guangzhou Occupational Disease Prevention and Control Institute was commissioned by 157 factories to carry out the occupational health inspection,including 14396 workers who were exposed to noise.Combined with the occupational health examination,a total of 3508 noise-exposed workers with blood routine,fasting blood glucose,blood lipids,and pure sound hearing examination were selected,including 2969 men and 539 women.Data including general information,occupational exposure history,and history of auditory system disease were collected at the meantime.The correlation between NIHL and WBC was determined by t-test and analysis of covariance,and correlation with elevated WBC was analyzed by logistic regression analysis.Results T-test of two independent samples and covariance analysis after adjusting for gender,age,noise-exposed years,fasting blood glucose,total cholesterol,and triacylglycerol both suggested that the WBC in the NIHL group was higher than that in the normal hearing group[(7.15±0.06)×10^(9)/L vs.(6.91±0.03)×10^(9)/L,(6.94±0.07)×10^(9)/L vs.(6.79±0.04)×10^(9)/L],with statistically significant differences(t=-3.912,P<0.001;F=5.618,P=0.018).After adjusting for gender,age,noise-exposed years,fasting blood glucose,total cholesterol,and triacylglycerol,logistic regression analysis showed that compared with the normal hearing group,the risk of elevated WBC increased by 32%in the NIHL group,and the odds ratio was 1.32(95%confidence interval:1.03-1.70,P<0.05).Conclusions NIHL is independently associated with elevated WBC.It is suggested that noise exposure may induce chronic inflammatory response.

关 键 词：白细胞计数 噪声性听力损失 噪声作业 

分 类 号：R135.8[医药卫生—劳动卫生]