COPD并发肺动脉高压患者血清OPG水平的变化及临床意义  

Changes of serum OPG level in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its clinical significance

作　　者：王欣宇 马晶晶 贾睿奕 杨林瀛[1] 姜锋[1] 庞桂芬[1] WANG Xinyu;MA Jingjing;JIA Ruiyi;YANG Linying;JIANG Feng;PANG Guifen(Department of Respiratory and Critical Care Medicine,The Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院呼吸与危重症医学科,河北承德067000

出　　处：《西部医学》2023年第1期121-124,129,共5页Medical Journal of West China

基　　金：2022年度河北省医学科学研究课题计划(20220428)。

摘　　要：目的观察慢性阻塞性肺疾病(COPD)并发肺动脉高压(PH)患者血清骨保护素(OPG)水平的变化,探究其临床应用价值。方法选取2020年12月~2021年12月于我院住院治疗的COPD患者120例作为观察组,依据超声心动图结果,将患者分为COPD组、COPD并发PH(COPD-PH)组,COPD-PH组分为轻度、中度及重度PH组,选取同期健康体检者49例作为对照组。检测并比较各组血清OPG水平。结果COPD-PH组患者血清OPG水平高于COPD组,且两组均高于对照组,差异有统计学意义(P<0.05);重度PH组患者血清OPG水平高于中度PH组,且两组均高于轻度PH组,差异有统计学意义(P<0.05);相关性分析结果显示,血清OPG水平与PASP、PLR、NLR、CRP、NT-Pro BNP呈正相关(r_(s)=0.463,0.278,0.396,0.285,0.273,P<0.05),与氧合指数呈负相关(r_(s)=0.415,P<0.001)。结论慢阻肺并发肺动脉高压患者血清OPG水平升高,且与肺动脉高压程度相关,动态观察该指标或可监测慢阻肺患者肺动脉高压的发生、发展。Objective To observe the changes of serum osteoprotegerin(OPG)level in patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary hypertension(PH)and explore its clinical value.Methods 120 COPD patients hospitalized in our hospital from December 2020 to December 2021 were selected as the observation group.According to the results of echocardiography,the patients were divided into COPD group and COPD complicated with PH(COPD-PH)group.The COPD-PH group was divided into mild,moderate and severe PH groups,and 49 healthy subjects were selected as the control group in the same period.The levels of serum OPG in each group were detected and compared.Results The level of serum OPG in COPD-PH group was higher than that in COPD group,and both groups were higher than that in the control group(P<0.05);The serum OPG level in severe PH group was higher than that in moderate PH group,and both groups were higher than that in mild PH group(P<0.05);The results of correlation analysis showed that serum OPG level was positively correlated with PASP,PLR,NLR,CRP and NT-proBNP(r_(s)=0.463,0.278,0.396,0.285,0.273,P<0.05),and negatively correlated with oxygenation index(r_(s)=0.415,P<0.001).Conclusion The level of serum OPG in patients with COPD complicated with pulmonary hypertension increases,which is related to the degree of pulmonary hypertension.Dynamic observation of this index may monitor the occurrence and development of pulmonary hypertension in patients with COPD.

关 键 词：骨保护素 慢性阻塞性肺疾病 肺动脉高压 

分 类 号：R563.9[医药卫生—呼吸系统] R544.1[医药卫生—内科学]