纳洛酮治疗对急性酒精中毒患者临床疗效、肝功能及β-EP、MDA水平的影响  

Effects of Naloxone Treatment on Clinical Efficacy,Liver Function and Levels ofβ-EP and MDA in Patients with Acute Alcoholism

作　　者：赵景芹 张颖[1] 王殿林[1] 杨海鹏[2] ZHAO Jing-qin;ZHANG Ying;WANG Dian-lin;YANG Hai-peng(Department of Emergency Infusion Room,the First People's Hospital of Shangqiu,Shangqiu 476100,Hennan Province,China;Henan Provincial Chest Hospital,Zhengzhou 450008,Hennan Province,China)

机构地区：[1]商丘市第一人民医院急诊输液室,河南商丘476100 [2]河南省胸科医院,河南郑州450008

出　　处：《罕少疾病杂志》2023年第1期52-54,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划项目(LHGJ20190762)

摘　　要：目的探讨急性酒精中毒患者采用纳洛酮治疗对临床疗效、肝功能及β-内啡肽(β-EP)、丙二醛(MDA)水平的影响。方法选取2020年1月至2022年5月在本院收治的急性酒精中毒患者共计92例,按照随机摸球法分成研究组(n=46)和对照组(n=46),研究组男性27例,女性19例,年龄(38.76±5.43)岁,对照组男性26例,女性20例,年龄(38.82±5.49)岁,对照组给予常规治疗,研究组给予纳洛酮治疗,比较两组临床疗效、症状消失时间、肝功能、β-EP、MDA水平及不良反应,计数资料采用2检验,计量资料采用独立样本t检验或配对资料t检验。结果研究组(97.83%)治疗总有效率与对照组(82.61%)相比更高(P<0.05);研究组症状消失时间与对照组相比更短(P<0.05);两组治疗后谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)、谷氨酰转移酶(GGT)水平均降低(P<0.05),研究组与对照组相比AST[(32.43±3.34)U/L比(34.52±3.81)U/L]、ALT[(29.82±3.25)U/L比(34.16±3.57)U/L]、γ-GT[(24.08±3.22)U/L比(27.96±3.45)U/L]、GGT[(145.86±21.34)IU/L比(167.33±25.67)IU/L]更低(P<0.05);两组治疗后β-EP、MDA水平降低(P<0.05),研究组与对照组相比β-EP[(85.42±15.46)ng/L比(131.71±28.71)ng/L]、MDA[(10.19±3.21)nmol/mL比(14.08±4.03)nmol/mL]更低(P<0.05);研究组与对照组不良反应发生率(10.87%比8.70%)比较差异无统计学意义(P>0.05)。结论急性酒精中毒患者采用纳洛酮治疗的临床疗效较高,可有效缩短症状消失时间,改善肝功能及β-EP、MDA水平,且安全性较高。Objective To explore the effect of naloxone treatment on clinical efficacy,liver function and levels ofβ-endorphin(β-EP)and malondialdehyde(MDA)in patients with acute alcoholism.Methods A total of 92 patients with acute alcoholism who were treated in our hospital from January 2020 to May 2022 were selected,and they were divided into the study group(n=46)and the control group(n=46)by the random touch-ball method.27 males and 19 female in the study group,aged(38.76±5.43)years old,26 male and 20 female in the control group,aged(38.82±5.49)years old.The control group was given routine treatment,and the research group was given naloxone treatment.The clinical efficacy,symptom disappearance time,liver function,β-EP,MDA levels and adverse reactions were compared of the two groups.The enumeration data using x2 test,measurement data using independent samples t test or paired data t test.Results Compared with the control group(82.61%),the total effective rate of the study group(97.83%)was higher(P<0.05).The symptom disappearance time of the study group was shorter than that of the control group(P<0.05).The levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamyl transpeptidase(γ-GT),and glutamyl transferase(GGT)were all decreased(P<0.05),compared with the control group,AST[(32.43±3.34)U/L vs.(34.52±3.81)U/L],ALT[(29.82±3.25)U/L vs.(34.16±3.57)U/L],γ-GT[(24.08±3.22)U/L vs.(27.96±3.45)U/L],GGT[(145.86±21.34)IU/L vs.(167.33±25.67)IU/L]in the study group were lower(P<0.05).After treatment,the levels ofβ-EP and MDA in the two groups were decreased(P<0.05),compared with the control group,β-EP[(85.42±15.46)ng/L vs.(131.71±28.71)ng/L],MDA[(10.19±3.21)nmol/mL vs.(14.08±4.03)nmol/mL]in the study were lower(P<0.05).In the incidence of adverse reactions,there was no significant difference of the study group and the control group(10.87%vs 8.70%)(P>0.05).Conclusion The clinical efficacy of naloxone in the treatment of patients with acute alcoholism is high,it can effectively shorten the ti

关 键 词：纳洛酮 急性酒精中毒 临床疗效 肝功能 β-内酚酞 丙二醛 

分 类 号：R595.6[医药卫生—内科学]