Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation  

作　　者：Kai-Long Ji Yao-Yue Fan Hio-Ha Kuok Qun-Fang Liu Ting Li Jian-Min Yue 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203 [2]State Key Laboratory of Quality Research in Chinese Medicines,Macao Institute for Applied Research in Medicine and Health,Macao University of Science and Technology,Macao 999078

出　　处：《CCS Chemistry》2021年第2期844-858,共15页中国化学会会刊（英文）

基　　金：supported financially by the grants(nos.21532007 and 21772213)from the National Natural Science Foundation of the People’s Republic of China.

摘　　要：Four unprecedented macrocyclic nonapeptides,orberryamides A–D(1–4),were isolated from Glycosmis pentaphylla(orangeberry)and structurally characterized by obtaining solid data from numerous analytical measurements.Compound 1 incorporated a new amino acid residue,named orangeberrine(Orgb),compounds 2 and 3 integrated the rare,nonproteinogenic amino acid residues(Kyn and Dioia,respectively),and compound 4 existed as two major conformational isomers in solution at ambient temperature.The biosynthetic pathways proposed for compounds 1–4 are of considerable biological significance for the modification and metabolism of tryptophan(Trp)and/or Trp containing proteins in nature.Besides,compounds 1–4 suppressed Th17 differentiation significantly,and the effects of 1–3 was achieved through targeting the ligand-binding domain(LBD)of the retinoic acid-related orphan receptor gamma t(RORγt).

关 键 词：natural products Glycosmis pentaphylla cyclopeptides Th17 differentiation inhibitors RORγt LBD blockers 

分 类 号：O62[理学—有机化学]