中药类保健食品中汞含量的3种测定方法  

Determination of Mercury Content in Traditional Chinese Medicine Health Food by Three Methods

作　　者：孟珊 刘晓明 邵阳 平惠娟 段琼 封淑华 MENG Shan;LIU Xiaoming;SHAO Yang;PING Huijuan;DUAN Qiong;FENG Shuhua(Hebei Institute for Drug and Medical Device Control,Hebei Shijiazhuang 050000,China;Hebei Center for Drug Evaluation,Hebei Shijiazhuang 050000,China)

机构地区：[1]河北省药品医疗器械检验研究院,河北石家庄050000 [2]河北省药品审评中心,河北石家庄050000

出　　处：《河北师范大学学报（自然科学版）》2023年第1期60-65,共6页Journal of Hebei Normal University：Natural Science

基　　金：河北省中医药类科研计划项目(2019193)。

摘　　要：采用高效液相色谱电感耦合等离子体质谱(HPLCICPMS)法、微波消解ICPMS法和直接进样测汞法测定23批次中药类保健食品中的总汞含量.测定结果表明,3种测定方法的线性相关系数(R)均大于0.999,回收率为80.2%~100.7%,相对标准偏差(RSD)为1.6%~5.3%;HPLCICPMS法能够准确、高效地测定3种汞形态化合物的含量,且测定的总汞含量与其他2种方法基本一致;总汞含量的测定应优先选择直接进样测汞法.The total mercury content in 23 batches of traditional chinese medicine health food was determined by HPLC-ICP-MS,microwave digestion ICP-MS and direct mercury injection method.The test results showed that the linear correlation coefficients(R)of the three methods are greater than 0.999,the recoveries are 80.2%~100.7%,and the relative standard deviations(RSD)are 1.6%~5.3%.The HPLC-ICP-MS method can accurately and efficiently determine the contents of the three different mercury compounds,and the total mercury contents are basically consistent with that of the other two methods.The direct mercury injection method should be preferred for the determination of the total mercury content.

关 键 词：汞含量 HPLCICPMS ICPMS 直接进样测汞法 

分 类 号：O175.2[理学—数学]