用于深部组织微创及无创连续监测的柔性电子器件  

Minimally-invasive and non-invasive flexible devices for robust characterizations of deep tissues

作　　者：袁月辉 唐文杰 吴昊 陈士晟 任雪洋 胡本慧 顾宁 Yuehui Yuan;Wenjie Tang;Hao Wu;Shisheng Chen;Xueyang Ren;Benhui Hu*;Ning Gu(School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing 211166,China;Jiangsu Key Laboratory for Biomaterials and Devices,State Key Laboratory of Bioelectronics,School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China)

机构地区：[1]南京医科大学生物医学工程与信息学院,南京211166 [2]东南大学生物科学与医学工程学院,生物电子学国家重点实验室,江苏省生物材料与器件重点实验室,南京210096

出　　处：《中国科学：化学》2022年第11期2027-2044,共18页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金创新研究群体(61821002);国家自然科学基金(81971701);国家重点研发计划(2019YFA0210104);江苏省自然科学基金(BK20201352)资助项目。

摘　　要：深部组织信号与疾病间有着强烈的相关性,临床上对深部组织的检测诊断一般依赖于医学影像设备等大型仪器,成本高昂且不利于长期监测.不同于笨重的大型设备,微创及无创的柔性电子器件可以在体长期佩戴,实现深部组织信号的连续采集,有助于疾病的早期诊断,进行精准化、个性化治疗.在本综述中,我们讨论了深部组织的生理、生化信号的检测机制,重点分析器件的制备方法、关键性能指标以及数据无线传输技术.最后提出了该领域存在的挑战和可能的解决策略.Deep-tissue signals often have a strong correlation with disease.Clinical detection and diagnosis of deep tissue mostly rely on large-scale instruments such as medical imaging equipment,which is costly and not conducive to long-term monitoring.Different from bulky and large-scale equipment,minimally invasive and non-invasive flexible devices can be worn in the body for a long time to achieve continuous acquisition of deep tissue signals,which is conducive to early diagnosis of diseases and precise and personalized treatment.In this review,we discuss the detection mechanisms of physiological and biochemical signals in deep tissues,focusing on the device fabrication methods,key performance indicators,and wireless data transmission techniques.Finally,several grand challenges and feasible solutions in this field are presented.

关 键 词：柔性电子器件 深部组织感知 健康监测 

分 类 号：R318[医药卫生—生物医学工程] TN03[医药卫生—基础医学]