DCE-MRI与DWI对局部晚期宫颈癌放化疗后的临床预测价值  

Clinical Predictive Value of DCE-MRI and DWI in Locally Advanced Cervical Cancer After Radiotherapy and Chemotherapy

作　　者：刘福生[1] 郑后珍[1] 张兴芳[1] LIU Fu-sheng;ZHENG Hou-zhen;ZHANG Xing-fang(Nanjing Pukou District Central Hospital,Jiangsu Nanjing 211800)

机构地区：[1]南京市浦口区中心医院,江苏南京211800

出　　处：《中国医疗器械信息》2022年第24期32-34,共3页China Medical Device Information

摘　　要：目的:探讨局部晚期宫颈癌放化疗患者联合采用多期动态增强磁共振成像(DCE-MRI)和扩散加权成像(DWI)预测预后的临床价值。方法:选取2020年1月~2021年10月本院收治的52例局部晚期宫颈癌患者,全部患者均行放化疗,治疗前予以患者磁共振检查(MR),联合采用DCE-MRI和DWI,利用软件测定最大相对增强率(MRE)、达峰时间(TTP)、灌注参数容量转移常数(Ktrans)与扩散参数表观扩散系数(ADC)。治疗后随访6个月,评价临床疗效及预后,观察不同疗效及预后患者的指标差异。结果:52例患者放化疗后完全缓解(CR)11例、部分缓解(PR)14例、稳定(SD)15例、进展(PD)12例。随访6个月,42例患者生存,10例患者死亡。CR和PR患者的Ktrans低于SD和PD患者,ADC高于SD和PD患者,差异有统计学意义(P<0.05)。生存患者的Ktrans低于死亡患者,ADC高于死亡患者,差异有统计学意义(P<0.05)。结论:DCE-MRI联合DWI可以为临床评估局部晚期宫颈癌放化疗患者的临床疗效提供有价值的影像学依据,Ktrans与ADC亦可用于预测患者远期预后。Objective:To investigate the clinical value of multi-phase dynamic enhanced magnetic resonance imaging(DCE-MRI)and diffusion weighted imaging(DWI)in predicting the prognosis of patients with locally advanced cervical cancer.Methods:52 patients with locally advanced cervical cancer treated in our hospital from January 2020 to October 2021 were selected.All patients underwent radiotherapy and chemotherapy.Patients were examined by magnetic resonance imaging(MR)before treatment.Combined with DCE-MRI and DWI,the maximum relative enhancement rate(MRE),time to peak(TTP),perfusion parameters(Ktrans)and diffusion parameters(ADC)were measured by software.After treatment,the patients were followed up for 6 months to evaluate the curative effect of the two groups and observe the difference of prognostic indexes in different patients.Results:After radiotherapy and chemotherapy,there were 11 cases of complete remission(CR),14 cases of partial remission(PR),15 cases of stability(SD)and 12 cases of progression(PD).Followed up for 6 months,42 patients survived and 10 patients died.The Ktrans of Cr and PR patients were lower than that of SD and PD patients,and the ADC was higher than that of SD and PD patients(P<0.05).The Ktrans of surviving patients was lower than that of dead patients,and the ADC was higher than that of dead patients(P<0.05).Conclusion:DCE-MRI combined with DWI can provide valuable imaging basis for clinical evaluation of the clinical efficacy of radiotherapy and chemotherapy in patients with locally advanced cervical cancer.Ktrans and ADC can also be used to predict the long-term prognosis of patients.

关 键 词：晚期宫颈癌 放化疗 DCE-MRI DWI 预后 预测价值 

分 类 号：R737.33[医药卫生—肿瘤]