止痛如神汤治疗肛瘘手术患者的效果及对FN水平、疼痛程度的影响  

Effect of Zhitong Rushen decoction in the treatment of patients undergoing anal fistula surgery and its influences on FN level and pain degree

作　　者：冯利[1] 吴飞飞 王俊[2] FENG Li;WU Feifei;WANG Jun(Ankang Central Hospital,Ankang 725000;Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China)

机构地区：[1]安康市中心医院,陕西安康725000 [2]安康市中医医院,陕西安康725000

出　　处：《临床医学研究与实践》2023年第2期93-96,共4页Clinical Research and Practice

基　　金：安康市科学技术研究发展计划项目(No.AK2020-SF-11)。

摘　　要：目的 探讨止痛如神汤治疗肛瘘手术患者的效果及对纤维连接蛋白(FN)水平、疼痛程度的影响。方法 选取2018年12月至2020年12月我院收治的64例肛瘘手术患者作为研究对象,按照随机数字表法将其分为对照组和研究组,各32例。对照组采用地奥司明联合高锰酸钾治疗,研究组在对照组的基础上联合止痛如神汤治疗。比较两组的治疗效果。结果 研究组的治疗总有效率为93.75%,显著高于对照组的71.88%,差异具有统计学意义(P<0.05)。治疗前,两组的白细胞介素-6(IL-6)、FN水平比较,差异无统计学意义(P>0.05);治疗21 d后,研究组的IL-6水平低于对照组,FN水平高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的创面肉芽组织毛细血管数量、成纤维细胞数量比较,差异无统计学意义(P>0.05);治疗21 d后,研究组的创面肉芽组织毛细血管数量、成纤维细胞数量多于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的简明-麦-吉疼痛问卷(SF-MPQ)评分比较,差异无统计学意义(P>0.05);治疗21 d后,研究组的SF-MPQ评分低于对照组,差异具有统计学意义(P<0.05)。结论 止痛如神汤治疗肛瘘手术患者的效果显著,可提高FN水平,促进创面愈合,改善炎症反应,减轻疼痛程度。Objective To explore the effect of Zhitong Rushen decoction in the treatment of patients undergoing anal fistula surgery and its influences on fibronectin(FN) level and pain degree. Methods Sixty-four patients undergoing anal fistula surgery admitted in our hospital from December 2018 to December 2020 were selected as the research objects, and the patients were divided into control group and study group according to random number table method, with 32 cases in each group. The control group was treated with diosamine combined with potassium permanganate, and the study group was treated with Zhitong Rushen decoction on the basis of the control group. The therapeutic effect of the two groups was compared.Results The total effective rate of treatment of the study group was 93.75%, which was significantly higher than 71.88% of the control group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of interleukin-6(IL-6) and FN between the two groups(P>0.05);after 21 d of treatment, the IL-6 level in the study group was lower than that in the control group, the FN level was higher than that in the control group, and the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in the number of capillaries and fibroblasts in the wound granulation tissue between the two groups(P>0.05);after 21 d of treatment, the number of capillaries and fibroblasts in the wound granulation tissue of the study group were more than those of the control group, and the differences were statistically significant(P <0.05). Before treatment, there was no significant difference in Short-Form of McGill Pain Questionnaire(SF-MPQ) score between the two groups(P>0.05);after 21 d of treatment, the SF-MPQ score of the study group was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Zhitong Rushen decoction in the treatment of patients undergoing anal fistula surgery has

关 键 词：止痛如神汤 肛瘘手术 纤维连接蛋白 疼痛 

分 类 号：R657[医药卫生—外科学]