常州某社区中老年人群高尿酸血症检出现状及其影响因素的研究  

Investigation on the prevalence and influencing factors of hyperuricemia in middle-aged and elderly residents in a community of Changzhou

作　　者：毛桐俊 王芳[2] 孙国民 谈文峰[1] MAO Tongjun;WANG Fang;SUN Guomin;TAN Wenfeng(Department of Rheumatology and Immunology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院风湿免疫科,江苏南京210029 [2]南京医科大学第一附属医院心脏科,江苏南京210029 [3]皖南医学院第一附属医院,弋矶山医院风湿免疫科,安徽芜湖241001 [4]南京医科大学附属常州第二人民医院风湿免疫科,江苏常州213003

出　　处：《皖南医学院学报》2022年第6期547-550,共4页Journal of Wannan Medical College

基　　金：安徽省质量工程项目(2021yxjxzyk004);安徽省卫生和计划生育委员会科研计划项目(2016QK040)。

摘　　要：目的:了解常州青龙街道社区中老年人群高尿酸血症(HUA)检出率以及影响HUA发生的相关因素。方法:采集6125例在常州市社区进行健康体检者的年龄、性别、尿酸、血脂、腹部彩超、既往疾病史、体格检查等指标;分析HUA患病率,采用单因素、多因素logistics回归分析影响HUA相关因素。结果:常州青龙街道社区中老年人群HUA患病率为12.16%(745/6125),其中男性HUA检出率为19.47%(543/2789),高于女性HUA检出率6.06%(202/3336)(χ^(2)=255.841,P<0.001);HUA组与NUA组比较,HUA组年龄、SCr、BUN、ALT、AST、TG、BMI、脂肪肝(FLD)及高血压患病率均高于NUA组(P<0.05);HUA组HDL水平低于NUA组(P<0.001);多因素Logistic回归分析显示,SCr升高、BUN升高、AST升高、TG升高、患FLD、高BMI(超重/肥胖)均是发生HUA的危险因素(P<0.05);女性、HDL水平升高是发生HUA的保护因素(P<0.05)。结论:常州青龙街道社区中老年人群HUA患者中SCr升高、BUN升高、AST升高、TG升高、患FLD、高BMI均是发生HUA的危险因素,男性的HUA患病率高于女性,HDL升高是HUA的保护因素。Objective:To investigate the detection rate of hyperuricemia(HUA)and the factors affecting HUA prevalence in the middle-aged and elderly residents in Qinglong community of Changzhou city.Methods:The age,gender,levels of uric acid,blood lipid and other biochemical indicators,findings of abdominal color Doppler ultrasound,previous disease history and other information associated with physical examination were collected from 6125 subjects undergoing general health examination in the community of Changzhou city.The prevalence of HUA was analyzed,and the related factors affecting HUA were analyzed by univariate and multivariate logistic regression.Results:The prevalence of HUA was 12.16%(745/6125)in the middle-aged and elderly residents living in Qinglong community of Changzhou city,and males had higher prevalence of HUA than females[19.47%(543/2789)vs.6.06%(202/3336),χ^(2)=255.841,P<0.001].Compared with the NUA group,the age,SCr,BUN,ALT AST,TG,BMI,fatty liver disease(FLD)and the prevalence of hypertension were significantly higher in HUA group(P<0.05),and HDL level was lower in HUA group than in NUA group(P<0.001).Further analysis by multivariate regression model showed that elevated levels of SCr,BUN,AST and TG,decreased HDL and FLD,and high BMI were all risk factors for HUA(P<0.05),yet female,and increase of HDL level were the protective factors for HUA(P<0.05).Conclusion:HUA prevalence is associated with elevated levels of SCr,BUN,AST and TG,decreased HDL and FLD,and high BMI in the middle-aged and elderly population in Qinglong community of Changzhou city.Males have higher prevalence of HUA than females,and elevated HDL level is the protective factors for HUA.

关 键 词：高尿酸血症 中老年人群 常州 社区 

分 类 号：R589.7[医药卫生—内分泌] R181.3[医药卫生—内科学]