基于主题模型分析法挖掘国医大师夏桂成早发性卵巢功能不全的诊治规律  

Rule of Diagnosis and Treatment of Premature Ovarian Insufficiency of Traditional Chinese Medicine Master XIA Guicheng Based on Topic Model Analysis

作　　者：张岩[1] 胡荣魁[1] 陈赟[1] 谈勇[1] ZHANG Yan;HU Rongkui;CHEN Yun;TAN Yong(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210046

出　　处：《辽宁中医杂志》2022年第11期58-61,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：江苏省卫生厅科教强卫工程(YXZXB2016006)。

摘　　要：目的 基于主题模型分析法探究国医大师夏桂成教授(简称“夏师”)早发性卵巢功能不全(premature ovarian insufficiency, POI)的诊治规律。方法 基于夏师诊治的POI门诊病历数据库,建立“POI—临床表征—处方”模型,运用主题模型分析方法进行数据挖掘。结果 POI分布于主题1和3。主题1临床表征分布概率从高到低依次为急躁易怒、脉细弦、口干、锦丝状带下量少、盗汗等,处方分布概率从高到低依次为杞菊地黄汤合越鞠丸、杞菊地黄汤、麦味地黄汤合越鞠丸、杞菊地黄汤合钩藤汤、杞菊地黄汤、钩藤汤合越鞠丸等。主题3临床表征分布概率从高到低依次为便溏、大便先干后溏、泛酸、舌苔白腻、面部痤疮等,处方分布概率从高到低依次为参苓白术散、杞菊地黄汤合香砂六君子汤、清心健脾汤、滋肾生肝饮、钩藤汤合香砂六君汤、滋肾生肝饮、钩藤汤合异功散等。结论 “肾阴亏虚、癸水衰少、心肝火旺”是POI的主证型一,临床表现为急躁易怒、脉细弦、口干、锦丝状带下量少、盗汗、口疮、脉弦细及锦丝状带下缺如,夏师经后初期以杞菊地黄汤为主方,经后中期以滋肾生肝饮为主方,经后末期以补天五子种玉汤为主方;“脾胃气虚”为POI主证型二,临床主要表现为便溏,兼见大便先干后溏、泛酸、舌苔白腻、面部痤疮、经期延长、嘈杂、健忘、腰怕冷及带下量少,若脾胃气虚较甚,夏师以参苓白术散为主方,待脾胃强健后再图滋阴养血;若脾胃气虚不甚,杞菊地黄汤为主方,常合异功散或香砂六君子汤,越鞠丸、钩藤汤为常用合方。Objective To explore the rule of diagnosis and treatment of premature ovarian insufficiency(POI)of traditional Chinese medicine master XIA Guicheng(Master XIA for short)based on Topic Model analysis.Methods The data mining was carried out by Topic Model analysis based on the POI-clinical representation-prescription model from the POI outpatient database of Master XIA.Results POI was distributed over Topics 1 and 3.In Topics 1,the probability value of clinical representations from high to low in turn was irritability,thin pulse,dry mouth,morbid leucorrhea and night sweat.The probability value of prescriptions from high to low in turn was Qiju Dihuang Decoction combined with Yueju Pill(杞菊地黄汤合越鞠丸),Qiju Dihuang Decoction(杞菊地黄汤),Maiwei Dihuang Decoction combined with Yueju Pill(麦味地黄汤合越鞠丸),Qiju Dihuang Decoction combined with Gouteng Decoction(杞菊地黄汤合钩藤汤),Qiju Dihuang Decoction(杞菊地黄汤)and Gouteng Decoction combined wjith Yueju Pill(钩藤汤合越鞠丸).In Topics 3,the probability value of clinical representations from high to low in turn was loose stool,loose stool after dry stool,belching,pantothenic acid,white and greasy tongue coating and facial acne.The probability value of prescriptions from high to low in turn was Senling Baizhu Powder(参苓白术散),Qiju Dihuang Decoction combined with Xiangsha Liujunzi Decoction(杞菊地黄汤合香砂六君子汤),Qingxin Jianpi(清心健脾汤),Zishen Shenggan Yin(滋肾生肝饮),Gouteng Decoction combined with Xiangsha Liujunzi Decoction(钩藤汤合香砂六君汤)and Gouteng Decoction combined with Yigong Powder(钩藤汤合异功散).Conclusion“Deficiency of kidney Yin,decline of Tiangui,and excess of heart and liver fire”are the main syndrome types of POI.The clinical manifestations are irritability,thin pulse,dry mouth,morbid leucorrhea,night sweat and thin pulse.Qiju Dihuang Decoction is the main prescription in the early stage.Zishen Shenggan Yin is the main prescription in the middle st

关 键 词：早发性卵巢功能不全 中医药 名老中医 夏桂成 数据挖掘 

分 类 号：R711.75[医药卫生—妇产科学]