超极速脉搏波技术定量评估颈动脉弹性和MHR的相关性研究  

Study of ultrafast pulse wave technique in quantitatively evaluating correlation between carotid elasticity and monocyte/high density lipoprotein ratio

作　　者：吴林琳 朱正球[1] 张颖[1] 王银萍 何姗姗 季雯晶 刘福明[2] 邹冲[3] 黄辉[1] WU Linlin;ZHU Zhengqiu;ZHANG Ying;WANG Yinping;HE Shanshan;JI Wenjing;LIU Fuming;ZOU Chong;HUANG Hui(Department of Ultrasound Medicine,Jiangsu Provincial Hospital of Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;Department of Cardiology,Jiangsu Provincial Hospital of Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;GCP Center,Jiangsu Provincial Hospital of Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China)

机构地区：[1]江苏省中医院/南京中医药大学附属医院超声医学科,南京210029 [2]江苏省中医院/南京中医药大学附属医院心内科,南京210029 [3]江苏省中医院/南京中医药大学附属医院GCP中心,南京210029

出　　处：《重庆医学》2023年第1期45-49,共5页Chongqing medicine

基　　金：江苏省第十六批“六大人才高峰”创新人才团队项目(TD-SWYY-069);江苏省中医药管理局中医药科技发展计划重点项目(ZD201906);江苏省卫生健康委员会老年健康科研项目(LK2021005)。

摘　　要：目的探讨超极速脉搏波(ufPWV)技术评估颈动脉弹性和单核细胞与高密度脂蛋白胆固醇比值(MHR)的相关性。方法选取2018年1月至2021年6月于该院超声医学科行ufPWV检查的287名志愿者,根据MHR四分位法将研究对象分为Q1组(<3.56,n=71),Q2组(3.56~<4.75,n=72),Q3组(4.75~<6.05,n=72),Q4组(≥6.05,n=72),比较各组间颈动脉内中膜厚度(cIMT)及ufPWV指标。结果Q4组收缩起始脉搏波速度(PWV-BS)、收缩末期脉搏波速度(PWV-ES)、cIMT均高于其他组,差异有统计学意义(P<0.05)。Q3组PWV-BS、PWV-ES高于Q1、Q2组(P<0.05),而cIMT无明显差异(P>0.05)。Q1与Q2组间PWV-BS、PWV-ES、cIMT差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,MHR与PWV-BS(r=0.360,P<0.001)、PWV-ES(r=0.458,P<0.001)、cIMT(r=0.359,P<0.001)均呈正相关。多元线性逐步回归分析显示MHR、SBP是PWV-BS的独立影响因素,MHR、SBP、年龄及LDL-C是PWV-ES的独立影响因素。结论ufPWV技术可作为定量评估颈动脉弹性变化及动脉粥样硬化进展的可靠影像学手段。Objective To investigate the correlation between carotid elasticity and monocyte/high density lipoprotein ratio(MHR)by ultrafast pulse wave velocity(ufPWV)technique.Methods A total of 287 volunteers undergoing ufPWV in the ultrasound medicine department of this hospital from January 2018 to June 2021 were selected and divided into the four groups according to the MHR quartile method:group Q1(MHR<3.56,n=71),group Q2(3.56≤MHR<4.75,n=72),group Q3(4.75≤MHR<6.05,n=72)and group Q4(MHR≥6.05,n=72).The carotid intima media thickness(cIMT)and ufPWV indicators(PWV-BS and PWV-ES)were compared among the four groups.Results PWV-BS,PWV-ES and cIMT in the Q4 group were significantly higher than those in the other three groups,and the differences were statistically significant(P<0.05).PWV-BS and PWV-ES in the Q3 group were significantly higher than those in the Q1 group and Q2 group(P<0.05),while there was no significant difference in cIMT(P>0.05).There was no statistically significant difference in PWV-BS,PWV-ES and cIMT between the Q1 group and Q2 group(P>0.05).The Pearson correlation analysis results showed that MHR was positively correlated with cIMT(r=0.359,P<0.001),PWV-BS(r=0.360,P<0.001)and PWV-ES(r=0.458,P<0.001).The multiple linear stepwise regression analysis showed that MHR and SBP were the independent risk factors of PWV-BS,and MHR,SBP,age and LDL-C were the independent influencing factors of PWV-ES.Conclusion The ufPWV technique could serve as the reliable imaging measures for quantitatively evaluating the carotid artery elasticity changes and athero-sclerosis progress.

关 键 词：单核细胞与高密度脂蛋白胆固醇比值 超极速脉搏波 颈动脉弹性 内中膜厚度 

分 类 号：R445.1[医药卫生—影像医学与核医学]