卵母细胞非整倍性改变的研究进展  

The research progress of oocyte aneuploidy

作　　者：杨佳怡 李越 班利荣 张娜[1] 李静[1] 张岩 YANG Jiayi;LI Yue;BAN Lirong;ZHANG Na;LI Jing;ZHANG Yan(The First Clinical Medical College,Basic Medical College,Inner Mongolia Medical University,Hohhot,Inner Mongolia Autonomous Region 011011,China;Department of Genetics,Basic Medical College,Inner Mongolia Medical University,Hohhot,Inner Mongolia Autonomous Region 011011,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古自治区呼和浩特011011 [2]内蒙古医科大学基础医学院遗传学教研室,内蒙古自治区呼和浩特011011

出　　处：《安徽医药》2023年第2期222-225,共4页Anhui Medical and Pharmaceutical Journal

基　　金：内蒙古医科大学科技百万工程项目(YKD2018KJBW005);内蒙古医科大学第一临床医学院大学生“启蒙计划”项目(FYQMJH2020042)。

摘　　要：妊娠失败和胎儿流产的主要原因之一是卵母细胞的非整倍性改变,并且发生率随着母亲年龄的增大而增加,三体和单体(非整倍体)胚胎至少占人类妊娠的10%,对于接近生殖寿命终点的女性,发生率可能超过50%。导致非整倍体的错误几乎总是发生在卵母细胞中,但尽管进行了深入研究,潜在的分子基础仍然令人难以捉摸。现回顾最近的研究,探讨女性减数分裂中导致非整倍体的可能机制。One of the main causes of pregnancy failure and fetal abortion is aneuploidy of oocytes,and the incidence increases with maternal age.Trisomy and monomer(aneuploidy)embryos account for at least 10%of human pregnancies,and may exceed 50%for women near the end of reproductive life.Errors leading to aneuploidy almost always occur in oocytes.Despite intensive research,the underlying molecular basis has remained elusive.This review discusses recent researches on the mechanisms that lead to aneuploidy during oogenesis.

关 键 词：卵子发生 非整倍性 卵母细胞 母亲年龄 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]