门冬胰岛素联合大剂量维生素D方案对妊娠期糖尿病新生儿低钙血症的疗效分析  

Efficacy of Insulin Aspart Combined with High-dose Vitamin D regimen on Hypocalcemia in Neonates with Gestational Diabetes Mellitus

作　　者：许思慧 甄曼华 龙小云 招嘉淇 王雪 张映辉 XU Sihui;ZHEN Manhua;LONG Xiaoyun;ZHAO Jiaqi;WANG Xue;ZHANG Yinghui(Department of Obstetrics,Foshan Fosun Chancheng Hospital Co.Ltd,Foshan 528000,Guangdong,China)

机构地区：[1]佛山复星禅诚医院有限公司产科,广东佛山528000

出　　处：《中国药物滥用防治杂志》2022年第11期1607-1610,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：佛山市自筹经费类科技计划项目(编号:2020001005350)。

摘　　要：目的:探讨门冬胰岛素联合大剂量维生素D方案对妊娠期糖尿病新生儿低钙血症的疗效。方法:选取我院2020年9月1日—2021年12月31日收治的80例妊娠期糖尿病患者作为研究对象,依据随机数字表法分成常规组、观察组,各组40例。常规组单纯皮下注射门冬胰岛素,观察组予以门冬胰岛素联合大剂量维生素D治疗,比较两组患者及新生儿维生素D含量[25-(OH)D]缺乏情况、新生儿血钙及血糖情况、并发症情况。结果:观察组[25-(OH)D]缺乏率为57.50%,低于常规组的70.00%(P<0.05);观察组[25-(OH)D]水平高于常规组(P<0.05);观察组新生儿出生24 h、3 d血清总钙、游离钙、[25-(OH)D]水平、血糖水平高于常规组(P<0.05);观察组并发症发生率低于常规组(P<0.05)。结论:门冬胰岛素+大剂量维生素D方案治疗妊娠期糖尿病患者具有理想的效果,可有效提高患者及新生儿体内的[25-(OH)D]含量,改善机体甲状旁腺激素功能与胰岛素敏感性生化指标,降低并发症发生风险,具有应用安全性。Objective:To investigate the effect of insulin aspart combined with high-dose vitamin D regimen on hypocalcemia in neonates with gestational diabetes mellitus.Methods:A total of 80 patients with gestational diabetes mellitus admitted to our hospital from September 1,2020 to December 31,2021 were selected as the research objects.According to the random number table method,they were divided into routine group and observation group,with 40 cases in each group.The routine group was treated with subcutaneous injection of insulin aspart,and the observation group was treated with insulin aspart combined with high-dose vitamin D.The vitamin D content [25-(OH)D] deficiency,neonatal blood calcium and blood glucose,and complications were compared between the two groups.Results:The deficiency rate of [25-(OH)D] in the observation group was 57.50%,which was lower than 70.00% in the routine group(P<0.05).The level of [25-(OH)D] in the observation group was higher than that in the routine group(P<0.05).The levels of serum total calcium,free calcium,[25-(OH)D] and blood glucose in the observation group were higher than those in the routine group at 24 h and 3 d after birth(P<0.05).The incidence of complications in the observation group was lower than that in the conventional group(P<0.05).Conclusion:Insulin aspart + high-dose vitamin D regimen has an ideal effect in the treatment of patients with gestational diabetes,which can effectively increase the content of [25-(OH)D] in patients and newborns,improve the body‘s parathyroid hormone function and insulin sensitivity biochemical indicators,reduce the risk of complications,and has application safety.

关 键 词：门冬胰岛素 大剂量维生素D 妊娠期糖尿病 新生儿低钙血症 

分 类 号：R714.256[医药卫生—妇产科学]