米索前列醇在瘢痕子宫人工流产术前预处理中的应用效果  

Application Effect of Misoprostol in Pretreatment Before Artificial Abortion of Scar Uterus

作　　者：李乡栋 占建珍 LI Xiangdong;ZHAN Jianzhen(Fuzhou Changle District Maternal and Child Health Hospital,Fuzhou 350200,Fujian,China)

机构地区：[1]福州市长乐区妇幼保健院,福建福州350200

出　　处：《中国药物滥用防治杂志》2022年第11期1633-1636,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：福州市科技计划项目(编号;2020-WS-50)。

摘　　要：目的:探讨瘢痕子宫人工流产术前实施米索前列醇预处理的临床效果。方法:选取2021年5月—2022年5月我院实施人工流产术的118例瘢痕子宫患者为研究对象,按随机数字表法分为对照组与观察组,每组59例。对照组在超声引导下实施无痛人工流产术,观察组手术方法与对照组一致,并在术前3 h予以米索前列醇预处理,比较两组手术相关指标、氧化应激指标[血清脂质过氧化物(LPO)、晚期氧化蛋白产物(AOPP)、丙二醛(MDA)]及术后并发症发生情况。结果:观察组手术时间、术后住院时间、术后月经来潮时间短于对照组,术中出血量少于对照组(P<0.05);观察组术后24 h LPO、AOPP、MDA水平低于对照组(P<0.05);观察组术后并发症发生率为5.08%,低于对照组的16.95%(P<0.05)。结论:瘢痕子宫人工流产术前实施米索前列醇预处理,能够加快手术进程,管控手术出血量,同时还可避免减轻氧化应激反应,降低术后并发症风险,具有应用安全性。Objective:To investigate the clinical effect of misoprostol in pretreatment before artificial abortion of scarred uterus.Methods:A total of 118 patients with scar uterus who underwent artificial abortion in our hospital from May 2021to May 2022 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 59 cases in each group.The control group was treated with ultrasound-guided painless artificial abortion,and the observation group was treated with the same operation method as the control group,and misoprostol pretreatment was performed at 3 h before operation.The operation-related indicators,oxidative stress indicators [serum lipid peroxide(LPO),advanced oxidation protein product(AOPP),malondialdehyde(MDA)] and postoperative complications were compared between the two groups.Results:The operation time,postoperative hospital stay and postoperative menstruation time in the observation group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group(P<0.05).The levels of LPO,AOPP and MDA in the observation group were lower than those in the control group at 24 hours after operation(P<0.05).The incidence of postoperative complications in the observation group was 5.08%,which was lower than 16.95% in the control group(P<0.05).Conclusion:Misoprostol pretreatment before artificial abortion of scar uterus can accelerate the operation process,control the amount of bleeding,avoid mild oxidative stress reaction,reduce the risk of postoperative complications,and has application safety.

关 键 词：瘢痕子宫 人工流产术 米索前列醇 氧化应激指标 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]