实时剪切波弹性成像辅助诊断良性弥漫性甲状腺疾病及其评估治疗效果的价值研究  

Value of real-time shear wave elastography in auxiliary diagnosis of benign diffuse thyroid diseases and in assessment of therapeutic effect

作　　者：韩莹[1] 吴迪[1] 赵恒达 刘逸群[1] 胡健[2] HAN Ying;WU Di;ZHAO Heng-da(Department of Ultrasound,First Hospital of Qinhuangdao,Qinhuangdao 066000,China;不详)

机构地区：[1]秦皇岛市第一医院超声科,河北秦皇岛066000 [2]唐山市人民医院超声科,河北唐山063001

出　　处：《中国医学装备》2022年第12期80-84,共5页China Medical Equipment

基　　金：河北省医学科学研究重点课题计划(20191296)“超声造影在激光消融甲状腺结节疗效评估中的临床应用”;秦皇岛市科学技术研究与发展计划(201805A054)“实时剪切波弹性成像辅助诊断甲状腺疾病及治疗效果的评估”。

摘　　要：目的:探究实时剪切波弹性成像辅助诊断良性弥漫性甲状腺疾病及其评估治疗效果的价值。方法:选取医院收治的123例良性弥漫性甲状腺疾病患者,依据活检穿刺结果将其分为甲亢组(39例)、亚急性甲状腺炎组(50例)和桥本甲状腺炎组(34例)。三组患者入院后均给予常规二维+彩色超声检查,并在此基础上对患者进行实时超声剪切波成像检查。分析三组患者实时剪切波弹性成像弹性模量最大值(Max)、最小值(Min)、平均值(Mean)及取样框内弹性数据离散度值(SD);检测并比较血清TRAb抗体及TGAb与杨氏模量值相关性,同时比较三组患者治疗前后的杨性模量值变化情况。结果:三组患者实时剪切波弹性成像弹性模量Max、Min、Mean及SD比较,差异有统计学意义(F=576.40,F=162.51,F=114.06,F=271.85;P<0.05)。与甲亢组比较,亚急性甲状腺炎组的Max、Min及Mean显著升高,亚急性甲状腺炎组的SD显著下降,差异有统计学意义(t=17.51,t=9.75,t=6.46,t=11.12;P<0.05);桥本甲状腺炎组的Max、Min及Mean显著升高,SD显著上升,差异有统计学意义(t=29.99,t=21.25,t=16.83,t=14.37;P<0.05)。与亚急性甲状腺炎组比较,桥本甲状腺炎组的Max、Min、Mean及SD明显升高,差异有统计学意义(t=21.10,t=8.58,t=8.80,t=18.52;P<0.05)。三组患者杨氏模量值、血清TRAb及TGAb相比较,差异有统计学意义(F=52.89,F=27.98,F=130.63;P<0.05)。甲亢组与亚急性甲状腺炎组和桥本甲状腺炎组的杨氏模量值、血清TRAb及TGAb比较均显著升高,差异有统计学意义(t_(亚急性甲状腺炎组)=6.52,t=12.24,t=14.61;t_(桥本甲状腺炎组)=13.62,t=5.74,t=13.13;P<0.05),与亚急性甲状腺炎组比较,桥本甲状腺炎组的杨氏模量值、血清TRAb及TGAb明显升高,差异有统计学意义(t=3.47,t=3.16,t=6.95;P<0.05)。经Pearson相关性检验分析,血清TRAb抗体及TGAb抗体与杨氏模量值呈正相关(r=0.826,r=0.721;P<0.05);三组患者治疗后的杨氏模量值均显著�Objective:To explore the value of real-time shear wave elastography in auxiliary diagnosis of benign diffuse thyroid diseases and in assessment of therapeutic effect.Methods:123 patients with benign diffuse thyroid diseases treated in hospital were conveniently selected as the research objects of this experiment.According to the biopsy results,they were divided into hyperthyroidism group(39 cases),subacute thyroiditis group(50 cases)and Hashimoto thyroiditis group(34 cases).The three groups of patients underwent routine two-dimensional(2D)+color ultrasound after admission,and then,all patients underwent real-time ultrasound shear wave elastography examination on the basis of that.The maximum(Max),minimum value(Min)and mean value(Mean)of elasticity modulus of real-time ultrasonic shear wave elastography,and the standard deviation(SD)value of elastic data within sampling block of three groups were analyzed.The correlations of serum TRAb antibody and TGAb and Young modulus were detected and compared,respectively.In addition,the changes of Young modulus before and after treatment among three groups were compared.Results:The differences of max,min,mean and SD of elasticity modulus of real-time ultrasonic shear wave elastography among three groups were significant(F=576.40,F=162.51,F=114.06,F=271.85,P<0.05).Compared with hyperthyroidism group,the Max,Min and Mean values of subacute thyroiditis group significantly increased,and the SD value of that significantly decreased(t=17.51,t=9.75,t=6.46,t=11.12,P<0.05),and the Max,Min and Mean of Hashimoto thyroiditis group significantly increased but the SD of that significantly decreased(t=29.99,t=21.25,t=16.83,t=14.37,P<0.05).Compared with group,the Max,Min,Mean and SD of Hashimoto thyroiditis group significantly increased(t=21.10,t=8.58,t=8.80,t=18.52,P<0.05),respectively.The differences of the Young modulus,serum TRAb and TGAb among three groups were significantly(F=52.89,F=27.98,F=130.63,P<0.05),respectively.Compared with hyperthyroidism group,the values of Young modulus,se

关 键 词：实时剪切波弹性成像 良性弥漫性甲状腺疾病 穿刺活检 血清学检测 治疗效果 

分 类 号：R445.1[医药卫生—影像医学与核医学]