1-溴乙基乙酸酯的制备方法研究  

Study on the Preparation Method of 1-Bromoethyl Acetate

作　　者：王雄强 WANG Xiongqiang(Guangdong Titan Pharmaceutical Co.,Ltd.,Heyuan 517000,China)

机构地区：[1]广东立国制药有限公司,广东河源517000

出　　处：《生物化工》2022年第6期64-66,共3页Biological Chemical Engineering

摘　　要：目的:以往1-溴乙基乙酸酯的制备工艺中,存在反应原料(乙酰溴)不稳定、反应不易控制(乙醛沸点低导致)的问题,且乙醛具有致癌性,以及溴化氢作为反应物时,反应难以控制、物料配比不易确定、反应物利用率低等问题都亟需解决。方法:利用纳米四氧化三铁具有的纳米特性和磁性,研究1-溴乙基乙酸酯的制备方法。结果:纳米四氧化三铁既能降低催化剂用量、提高催化活性,也便于分离回收。选取二氯甲烷和氯仿混合剂(2∶1,v∶v)作为萃取剂时,所得产物的产率和纯度最高。结论:该方法工艺条件温和、易控,催化剂活性高,易回收,产品收率高、纯度高,同时具有环保、低成本的优点。Objective: In the previous preparation process of 1-bromoethyl acetate, there are problems such as unstable reaction materials(acetyl bromide), difficult reaction control(caused by low boiling point of acetaldehyde),carcinogenicity of acetaldehyde, and difficult reaction control, difficult material ratio determination and low utilization rate of reactants when hydrogen bromide is used as reactant. Methods: The preparation method of bromoethyl acetate is studied by using the nanometer characteristic and magnetism of nano ferric oxide. Results: Nanometer Fe3O4can not only reduce the amount of catalyst, improve the catalytic activity, but also facilitate the separation and recovery. When the mixture of dichloromethane and chloroform(2 ∶ 1, v ∶ v) is used as extractant, the yield and purity of the product are the highest. Conclusion: This method has the advantages of mild process conditions, easy control, high catalyst activity, easy recovery, high yield, high purity, high reaction efficiency, environmental protection and low cost.

关 键 词：1-溴乙基乙酸酯 制备方法 化学实验 

分 类 号：TQ463[化学工程—制药化工]