氢吗啡酮在剖宫产产妇术后镇痛的应用效果  

Study on the Application Effect of Hydromorphone in Postoperative Analgesia of Caesarean Parturients

作　　者：马丽 马旭[2] 陈辉[3] 张玲霞 于芝 MA Li;MA Xu;CHEN Hui;ZHANG Lingxia;YU Zhi(Ning′an Hospital of Ningxia,Yinchuan 750011,China;The Third Clinical Medical College of Ningxia Medical University,Yinchuan 750001,China;Department of Anesthesiology,People's Hospital of Ningxia Hui Autonomous Region,Ningxia Eye Hospital,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区宁安医院,银川750011 [2]宁夏医科大学第三临床医学院,银川750001 [3]宁夏回族自治区人民医院(宁夏眼科医院)麻醉科,银川750002

出　　处：《宁夏医科大学学报》2022年第11期1125-1128,共4页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金项目(NZ15188)。

摘　　要：目的观察氢吗啡酮在产妇剖宫产术后镇痛应用的效果。方法收集82例行剖宫产产妇,分为对照组(n=46)与治疗组(n=36)。比较两组产妇术后疼痛评分、镇静评分、术后肛门排气恢复时间、术后首次下床时间、首次下床活动持续时长、产妇术后24、48 h血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL^(-1)0)水平等指标及药物不良反应。结果治疗组产妇术后6、12、24、48 h疼痛评分、术后首次下床活动时间、首次下床活动持续时长、术后肛门排气恢复时间与对照组比较,差异均有统计学意义(P均<0.05),治疗组产妇术后6、12、24、48 h镇静评分、术后肛门排气恢复时间与对照组差异均无统计学意义(P均>0.05);对照组与治疗组产妇用药后不良反应发生率差异无统计学意义(P>0.05)。结论氢吗啡酮可提高产妇剖宫产术后镇痛效果,减少产妇术后炎性反应,促进产妇术后康复。Objective To study the analgesic effect of hydromorphone after cesarean section.Methods A total of 82 women with cesarean section in our hospital were divided into control group(n=46)and treatment group(n=36).Postoperative pain score,sedation score,postoperative recovery time of anal exhaust,time of first time getting out of bed,duration of first time getting out of bed,serum TNF-αand IL^(-1)0 levels and adverse drug reactions were compared between the two groups.Results There were statistical differences between the treatment group and the control group in pain score at 6 h,12 h,24 h and 48 h after operation,time of first ambulation,duration of first ambulation and recovery time of anal exhaust after operation(P all<0.05).There was no significant difference in the sedation score of the treatment group at 6 h,12 h,24 h,48 h after childbirth and the recovery time of anal exhaust after childbirth between the treatment group and the control group(P all>0.05).There was no significant difference in the incidence of adverse reactions between the control group and the treatment group(P>0.05).Conclusion Hydromorphone can significantly improve the analgesic effect after cesarean section,reduce the inflammatory reaction after childbirth and promote the postoperative recovery of puerpera.

关 键 词：氢吗啡酮 剖宫产 术后镇痛 临床应用 

分 类 号：R719.83[医药卫生—妇产科学]