关于DNA的时间生物学特征的猜想  

A hypothesis on chronobiological characteristics of DNA

作　　者：严冬[1] 鲁海峰[2] 方辉[3] 应佩君 肖党生[5] YAN Dong;LU Haifeng;FANG Hui;YING Peijun;XIAO Dangsheng(Department of Infectious Diseases,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;Emergency Department,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;Department of General Internal Medicine,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;Department of Geriatrics,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院传染科,浙江杭州310003 [2]浙江大学医学院附属第一医院传染病诊治国家重点实验室,浙江杭州310003 [3]浙江大学医学院附属第一医院急诊科,浙江杭州310003 [4]浙江大学医学院附属第一医院普通内科,浙江杭州310003 [5]浙江大学医学院附属第一医院老年科,浙江杭州310003

出　　处：《空军军医大学学报》2022年第1期123-126,共4页Journal of Air Force Medical University

基　　金：国家科技重大专项(2018ZX10101-001)。

摘　　要：生物节律是一种常见的生命现象。现今对生物节律的认识已经深入到蛋白质和基因水平。DNA分子结构和生物学功能决定了DNA具有时间生物学特征。在DNA和RNA的合成通路中,参与合成的关键激酶活性存在节律性变化,这种节律性变化保障了DNA中磷酸脱氧核糖链和RNA中磷酸核糖链的单纯性。DNA分子的时间生物学特征同氢键的形成密切相关,氢键形成的难易程度受到日夜温度波动的影响,这是DNA分子形成时间节律的因素之一。由此可以推测在晚间至午夜存在一个DNA复制和修复的最佳时间窗口。细胞的各种生物学功能也将围绕DNA的时间生物学特征进行周期性波动,相关分子生物学特征需要进行深入研究。Biorhythm is a general life phenomenon. Many researches on biorhythm focus on time-related proteins and genes. The molecular structure and biological function of DNA endow DNA with some chronobiological characteristics. In the pathways for synthesizing DNA and RNA, key kinase activity involved in the synthesis has periodical changes, which keeps phosphoribose chain of RNA and phosphate deoxyribose chain of DNA in purity. Biorhythms of DNA are closely related to the formation of hydrogen bonds that is affected by the fluctuation in temperature, which is one of the factors to form circadian rhythm of DNA. Therefore, a reasonable conclusion is that there is an optimal time window from evening to midnight for DNA synthesis and repairing. All behaviors of a cell are guided by circadian rhythm of DNA. More researches on the related molecular biological characteristics should be carried out.

关 键 词：脱氧核糖核酸 时间生物学 核糖核苷酸还原酶 胸苷酸合成酶 氢键 

分 类 号：R393[医药卫生—基础医学] Q52[生物学—生物化学]